氧化和三聚酸盐对素从基托基大颗粒中释放的素的影响
Alessandro Pistone1, Annamaria de Gaetano1, Elpida Piperopoulos1
1Department of Engineering, University of Messina, Contrada Di Dio, I-98166 Messina, Italy.
Materials (Basel, Switzerland)
|September 9, 2023
概括
基托 (CS) 大颗粒被合成用于黄素 (CUR) 输送. 不同的凝剂控制了CUR释放动力学,显示了各种应用的潜力.
科学领域:
- 材料科学 材料科学 材料科学
- 聚合物化学 聚合物化学
- 药物运输 药物运输 药物运输
背景情况:
- 酸盐 (CS) 是一种生物相容的聚合物,具有药物输送潜力.
- 黄素 (CUR) 是一种具有治疗性质但生物利用性有限的天然化合物.
- 开发有效的CUR传递系统对于其治疗应用至关重要.
研究的目的:
- 合成和表征裸体和CUR载荷的基于CS的宏观粒子.
- 研究不同凝剂 (氧化和三聚酸) 对宏粒物质和CUR释放动力学的影响.
- 评估开发的宏观颗粒的封装效率和胀行为.
主要方法:
- 离子凝被用于使用CS与NaOH或TPP进行宏粒体合成.
- 描述技术包括扫描电子显微镜 (SEM),富里埃变换红外光谱 (FTIR),热重力测量分析 (TGA) 和差分扫描热量测量 (DSC).
- 分析了黄素释放特征,封装效率和胀程度.
主要成果:
- 成功合成了基于CS的球形宏观粒子.
- 所有配方都显示出高CUR封装效率,超过90%.
- 在TPP交叉连接的宏粒中,表现出双相CUR释放:快速释放34%和缓慢释放66%的重量.
结论:
- 凝剂的选择及其度显著影响CS宏粒的特性和CUR释放动力学.
- 开发的CS宏粒能够高效地封装CUR.
- 这些基于CS的宏粒体提供可调节的CUR释放配置文件,表明它们适用于各种药物输送应用.
相关概念视频
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