软组织的实时非破坏性粘度测量基于粘弹性反应光学一致性弹性图形
Zhixin Liu1, Weidong Liu1, Qi Chen2
1China Automotive Technology and Research Center, Tianjin 300300, China.
Materials (Basel, Switzerland)
|September 9, 2023
概括
一种新的粘弹性响应-光学连贯弹性图 (VisR-OCE) 方法可以准确地实时测量软组织粘度. 这种非破坏性技术在疾病诊断和生物材料分析方面表现有前途.
科学领域:
- 生物医学工程 生物医学工程
- 光学成像技术的成像
- 生物物理学的生物物理.
背景情况:
- 软组织的粘弹性对于理解疾病,生物材料和组织特性至关重要.
- 精确测量粘性弹性有助于诊断和材料开发.
研究的目的:
- 引入一个实时的,高分辨率的粘弹性响应-光学连贯弹性图 (VisR-OCE) 方法.
- 为了确定 Kelvin-Voigt 材料的位移和放松时间常数之间的关系.
- 为了验证VisR-OCE方法的准确性和适用性.
主要方法:
- 使用声辐射力 (ARF) 激发和光学连贯性断层扫描 (OCT) 成像.
- 开发了一种基于连续ARF加载-卸载的方法来测量位移.
- 采用数值模拟来优化参数和评估材料影响.
主要成果:
- 数字模拟显示,在不同材料特性中,放松时间常数值的波动不到4%.
- 使用幻象的实验验证表明了VisR-OCE的准确性,结果与拉伸测试差异约3%.
- 该方法提供实时,高分辨率的粘弹性测量.
结论:
- 视R-OCE方法提供了一种可靠的方法来评估软组织粘性弹性.
- 这种技术使得生物组织的粘度测试能够快速而非破坏性地进行.
- 在疾病诊断和生物材料表征方面,VisR-OCE具有潜在的应用.
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