合成和特征的阿加洛斯水凝释放的迪克洛菲纳克
Anna Jarosz1, Oliwia Kapusta1, Dorota Gugała-Fekner1
1Faculty of Chemistry, Institute of Chemical Sciences, Maria Curie-Sklodowska University, Maria Curie-Sklodowska Sq. 3, 20-031 Lublin, Poland.
Materials (Basel, Switzerland)
|September 9, 2023
概括
用酸修饰的糖水凝显示了可调节的特性,用于控制药物释放. 酸含量影响机械特性和不同环境中的二甲释放率.
科学领域:
- 生物材料科学 生物材料科学
- 聚合物化学 聚合物化学
- 药物输送系统 药物输送系统
背景情况:
- 由于其3D聚合物网络结构,水凝是用于控制药物释放的多功能生物材料.
- 基于阿加罗斯的水凝提供了药物输送的潜力,但仍未得到充分探索.
- 控制释放系统对于有效和安全的治疗应用至关重要.
研究的目的:
- 为了合成和表征不同酸含量的亚加水凝.
- 调查酸对糖水凝机械和物理化学性质的影响.
- 为了评估从这些水凝中控制释放的迪克洛菲纳克在不同的介质中.
主要方法:
- 合成具有不同酸度的阿加罗斯水凝.
- 风学测量以评估机械性能.
- 减弱总反射-里埃变换红外光谱学 (ATR-FTIR) 用于化学表征.
- 在体外释放药物的研究中,使用水中的二甲,PBS和0.01 M NaOH.
主要成果:
- 添加酸改变了阿加水凝的机械和物理化学特性.
- 迪克洛芬雅克释放的速度受到酸含量的显著影响.
- 环境条件 (水,PBS,NaOH) 显著影响了药物释放特征.
- 在酸度和药物释放动力学之间观察到相关性.
结论:
- 用酸修改的以糖为基础的水凝是控制药物输送的有希望的平台.
- 可调节性质使得药物如二二的定制释放档案成为可能.
- 这些生物相容的水凝具有各种生物医学应用的潜力,需要控制释放.
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