自组装的聚合物用于胃肠道通过口腔途径的向输送:最新情况
Xiaoyu Yang1, Yang Yang2,3, Haiyan Yu2,3
1Department of Pharmacy, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
Polymers
|September 9, 2023
概括
自组装的纳米结构为胃肠道 (GIT) 疾病提供了增强的口服药物输送. 这些系统保护治疗药物免受降解,提高治疗疗效,减少局部结肠疾病的副作用.
科学领域:
- 制药科学 制药科学
- 生物材料科学 生物材料科学
- 纳米技术 纳米技术
背景情况:
- 胃肠道 (GIT) 向药物输送系统对于治疗局部结肠疾病至关重要.
- 保护易于在上部GIT降解的治疗药物可以提高口服的效率,并减少副作用.
- 自组装的纳米结构 (菌体,水凝,脂质体) 提供刺激响应和可修改的平台,用于有针对性的传递.
研究的目的:
- 审查和批判性地讨论天然和合成生物材料对GIT药物向的药物重要性.
- 评估自组装方法的治疗可行性,以有效地将药物输送到胃肠道.
- 突出基于聚合物的纳米结构的潜力,以有针对性的口服药物输送.
主要方法:
- 关于用于GIT药物输送的自组装纳米结构的现有文献的审查.
- 在这些系统中使用的天然和合成生物材料的分析.
- 对自组装方法的评估,以创建有针对性的纳米载体.
主要成果:
- 自组装的纳米结构显示出在GIT内有针对性的药物输送的巨大潜力.
- 基于天然和合成聚合物的纳米结构表现出有希望的pH响应性和受控释放特性.
- 在GIT中的微生物降解有助于从这些纳米结构中局部释放药物.
结论:
- 自组装为开发高效的GIT向药物递送系统提供了一个可行的策略.
- 基于聚合物的纳米结构特别有效,因为它们具有局部结肠疾病治疗的固有特性.
- 这些先进的输送系统承诺改善治疗结果,并尽量减少全身副作用.
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