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聚合物平板电脑矩阵系统用于控制释放干燥的Betula pendula 叶子提取物

Dimitar Penkov¹, Paolina Lukova², Hristo Manev³

¹Department of Pharmaceutical Sciences, Faculty of Pharmacy, Medical University of Plovdiv, 4002 Plovidv, Bulgaria.

|September 9, 2023

概括

聚合物矩阵片被开发用于修改释放Betula pendula叶提取物. 配方参数如聚合物比率和压缩力显著控制药物释放,达到持续释放长达7.97小时.

科学领域:

制药技术制药技术制药技术
药物输送系统药物输送系统
聚合物科学聚合物科学

背景情况:

贝图拉 (Betula pendula) 的叶子提取物具有治疗性质.
控制药物释放系统对于优化治疗疗效和患者遵守至关重要.
开发有效的聚合物矩阵用于天然产品提取物提出了配方挑战.

研究的目的:

开发聚合物矩阵片,用于修改释放Betula pendula叶提取物.
调查配方参数对药物释放动态的影响.
为了优化平板电脑组合,以持续的药物输送.

主要方法:

使用3^3的因数设计研究乙烯纤维素 (EC) /基基甲基纤维素 (HPMC) 的比率,HPMC的分子量和压缩力.
制定了27种不同参数组合的药片型号.
分析药物释放概况,特别是t80值,使用统计方法,包括Tukey测试和ANOVA.

主要成果:

确定25/75 (EC/HPMC) 比率是延长释放的最佳情况.
增加的HPMC分子量 (750-1150 kDa) 和更高的压缩力 (高达2 t) 显著增强了持续的药物释放 (t80高达7.97 h).
水友性HPMC和疏水性EC的组合创造了一个有前途的药物载体矩阵.

结论:

配方参数显著影响聚合物矩阵片中的药物释放率.
优化的配方可以实现控制和持续释放Betula pendula叶提取物.
这项研究表明了EC/HPMC矩阵在开发有效的修改释放药物递送系统方面的潜力.

关键词:

乙烯基纤维素酸是什么基烯基甲基纤维素.植物提取物植物提取物聚合物片类的聚合物片.持续释放持续释放持续释放

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