血清安纳米德和与林诺基酸相关的脂质可以区分间歇性囊炎/膀疼痛综合征与过度活跃的膀:一项探索性研究
Kazumasa Torimoto1, Tomohiro Ueda2, Daisuke Gotoh1
1Department of Urology, Nara Medical University, Nara, Japan.
Lower urinary tract symptoms
|September 9, 2023
概括
血清安纳米德显示为诊断间歇性囊炎/膀疼痛综合征 (IC/BPS) 的生物标志物具有前途. 这种血液生物标志物的较低水平可能表明IC/BPS的疼痛和炎症特征.
科学领域:
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 生物化学 生物化学
- 医学诊断 医学诊断 医学诊断
背景情况:
- 诊断间歇性囊炎/膀疼痛综合征 (IC/BPS) 是具有挑战性的,因为依赖主观症状和经验性囊镜.
- 需要客观的生物标志物来区分IC/BPS和具有类似症状的疾病,例如过度活性膀 (OAB).
研究的目的:
- 为了确定血液基生物标志物,能够区分IC/BPS和OAB.
- 探索潜在的代谢途径参与IC/BPS病原体.
主要方法:
- 对323种代谢物的血清代谢分析在被诊断为亨纳型IC,膀疼痛综合征,OAB的患者和健康对照进行.
- 液体染色学飞行时间质谱法用于代谢物概况.
- 用验证的IC/BPS指数评估症状严重程度.
主要成果:
- 与OAB和对照组相比,IC/BPS患者的安纳米德相对血清水平明显较低.
- 安南胺在IC/BPS和其他条件之间表现出高的区分能力 (AUC=0.9321).
- 在IC/BPS患者中,其他代谢物,包括乙卡尼丁 (18:2),林诺乙醇胺和阿拉基酸,也发生了变化.
结论:
- 血清胺是IC/BPS的潜在诊断生物标志物.
- 降低的安纳米德水平可能与IC/BPS中心的疼痛和炎症相关.
- 异常的林诺酸代谢与IC / BPS的发展有关.
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