概括
在接受抗生素治疗的血液癌症患者中,口服安福特里辛B显著降低了全身候群病症. 这表明胃肠道是Candida albicans感染的主要入口点.
科学领域:
- 医学真菌学 医学真菌学
- 血液学 血液学 血液学
- 传染性疾病 传染性疾病
背景情况:
- 血液性恶性瘤增加了对机会性感染的易感性.
- 在这些患者中使用抗生素可以破坏肠道微生物群,促进真菌过度生长.
- 扩散性角膜炎是免疫功能低下个体的严重并发症.
研究的目的:
- 为了评估口服安波特里辛B在预防全身候选性感染方面的疗效.
- 为了确定胃肠道是否可以作为Candida albicans在这个患者群体中的入口门.
主要方法:
- 这是一项双盲,安慰剂控制的研究,涉及72名患有血液性恶性瘤的患者.
- 患者接受了口服安福特里辛B (50毫克每天四次) 或与之匹配的安慰剂.
- 进行了解剖检查,以评估散播型 кандидоз的组织病理证据.
主要成果:
- 在24%的安慰剂受试者 (8/33) 中发现了散布的候选症.
- 只有5%的患者接受口服安福特里辛B (2/39) 显示有传播性角膜病的证据.
- 随着口服安福特里辛B的使用,观察到系统性候选性感染的统计显著减少.
结论:
- 口服安福特里辛B在接受抗生素的血液癌症患者中有效降低系统性候选性感染的发生率.
- 胃肠道是Candida albicans在这个脆弱人群中进入的重要门户.
- 预防性口服抗真菌治疗可能有助于预防免疫受损患者的侵入性真菌感染.
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