在汉族中国高血压患者中,甘油三糖指数和功能下降
Hung-Chang Chen1,2, Yun-Hsuan Tsai1,2,3, Chin-Chou Huang2,4,5
1Department of Medical Education, Taipei Veterans General Hospital, Taipei, Taiwan.
Journal of clinical hypertension (Greenwich, Conn.)
|September 9, 2023
概括
三甘油糖 (TyG) 指数与高血压患者功能下降的风险较高有关. 这项研究发现,提升的TyG指数独立地预测了该人群估计的膜过率 (eGFR) 的恶化.
科学领域:
- 心脏病学 心脏病学
- 腎臟病學 (nephrology) 是一種醫學專業.
- 代谢综合征是代谢综合征的一种.
背景情况:
- 升高的甘油三糖 (TyG) 指数是心血管疾病的已知危险因素.
- 高血压是导致慢性病和功能下降的主要原因.
- 在高血压患者中,TyG指数与功能下降之间的关系需要进一步研究.
研究的目的:
- 在患有基本高血压的患者中,研究甘油三指数 (TyG) 与功能下降之间的关联.
- 确定TyG指数是否是该队列中事件的独立预测指标.
主要方法:
- 研究了一组548名汉族中华人患有基本高血压的患者.
- 甘油三糖 (TyG) 指数是使用禁食甘油三糖和葡萄糖水平计算的.
- 功能下降被定义为估计膜过率 (eGFR) 的>25%下降.
- 考克斯比例危险回归模型被用来评估TyG指数对事件的独立影响.
主要成果:
- 在平均4.7年的随访期间,97名患者经历了EGFR>25%的下降.
- 患有eGFR下降的患者表现出显著更高的禁食甘油三,禁食葡萄糖和TyG指数水平.
- 泰格指数 (HR=1.490,P=0.041) 被确定为事件的独立预测指标,与办公室缩血压,糖尿病和基线eGFR一起.
结论:
- 在高血压患者中,增加的甘油三糖 (TyG) 指数独立地与估计球过率 (eGFR) 降低的风险增加有关.
- 泰格指数可以作为一个有价值的生物标志物,用于预测高血压患者的功能恶化.
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