根据动脉样硬化心血管疾病状态,发生性心力衰竭的预测因素的差异
Luke P Dawson1,2,3, Melinda J Carrington4, Tilahun Haregu1,4
1Department of Cardiology, The Alfred Hospital, Melbourne, Victoria, Australia.
ESC heart failure
|September 9, 2023
概括
心力衰竭的危险因素是多样化的,包括社会人口统计,生活方式和心脏代谢健康. 这些因素在很大程度上预测了心力衰竭 (HF) 发生率的一致性,无论是否存在动脉样硬化心血管疾病 (ASCVD).
科学领域:
- 心脏病学 心脏病学
- 公共卫生 公共卫生
- 流行病学 流行病学
背景情况:
- 心力衰竭 (HF) 构成了全球重大健康负担,导致大量的发病率和死亡率.
- 识别各种风险因素对于有效的预防和管理战略至关重要.
- 风险因素的概况可能会根据动脉样硬化心血管疾病 (ASCVD) 的存在而有所不同.
研究的目的:
- 调查事件HF与基础风险因素综合集之间的关联.
- 确定这些关联是否在具有和没有确定的ASCVD的个体中存在差异.
主要方法:
- 分析了来自贝克生物银行队列的5758名参与者,没有基线HF.
- 事件HF定义为住院或HF相关死亡,随访时间中位数为12.2年.
- 多变量回归模型根据社会人口统计学,生活方式,心脏代谢和并发症因素进行调整.
主要成果:
- 在65,987人年以上的参与者中,13.6%的参与者发生了HF事件.
- 与没有 (4.2%) 相比,ASCVD患者 (32.4%) 观察到更高的HF发病率.
- 关键预测因素包括年龄,社会经济地位,酒精摄入量,吸烟,BMI,腰围,SBP,LDL-C和HDL-C,在ASCVD状态上基本一致的关联,尽管糖尿病在非ASCVD患者中显示出更强的联系.
结论:
- 发生性HF与广泛的社会人口统计学,生活方式,心脏代谢和并发症因素有关.
- 这些风险因素与HF发病率的相关性在很大程度上是一致的,不论ASCVD是否存在.
- 这些发现支持为一般人群和ASCVD患者开发风险预测模型.
更多相关视频
04:05Author Spotlight: Unveiling Prognostic Indicators in Heart Failure - The Role of Phase Angle and Bioelectrical Impedance Analysis
Published on: June 30, 2023
1.9K
14:35Post-Myocardial Infarction Heart Failure in Closed-chest Coronary Occlusion/Reperfusion Model in Göttingen Minipigs and Landrace Pigs
Published on: April 17, 2021
8.6K
相关概念视频
01:30Heart Failure IV: Classification and Diagnostic Evaluation
19
Heart failure can be classified in various ways, with the most common classifications based on physical activity limitations, disease progression, severity, and treatment strategies.The Functional Classification of Heart Failure divides patients into four categories based on physical activity limitation due to symptom burden.Class I: Patients in this class have cardiac disease but no physical activity limitations. Ordinary activities like walking, climbing stairs, or routine tasks do not cause...
19
01:17Pathophysiology of Heart Failure
1.6K
Heart failure (HF) is a progressive syndrome involving ventricles that leads to inadequate cardiac output. It can be classified based on location and output or ejection fraction. Ejection fraction (EF) is an essential measurement in the diagnosis and surveillance of HF. Reduced EF corresponds to systolic heart failure (HFrEF). However, HF with preserved ejection fraction (HFpEF) is becoming increasingly prevalent. Also known as diastolic HF, this form of HF is related to aging. The...
1.6K
01:27Heart Failure I: Introduction
14
Heart failure refers to a clinical syndrome caused by structural or functional cardiac disorders that prevent the heart from pumping an adequate amount of blood to meet the body's metabolic needs. This condition often arises from myocardial infarction or ischemia, leading to decreased cardiac output, reduced tissue perfusion, impaired gas exchange, fluid volume imbalance, and decreased functional ability.Heart failure can result from disruptions in the mechanisms that regulate cardiac output...
14
01:30Coronary Artery Disease I: Introduction
20
Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
20
01:27Atherosclerosis II: Clinical Manifestations and Diagnostic Tests
13
Atherosclerosis is a progressive disorder that leads to the thickening and narrowing of arterial walls due to plaque buildup. This condition can cause various symptoms depending on the arteries affected:Coronary Artery Disease (CAD): This condition affects the coronary arteries and may lead to chest pain (angina), shortness of breath (dyspnea), heart attacks, and other heart disease symptoms.Cerebrovascular Disease: This affects blood flow to the brain, causing transient ischemic attacks (TIAs)...
13
01:29Heart Failure II: Pathophysiology
15
Systolic Heart Failure and Compensatory MechanismsSystolic heart failure (also termed HFrEF, Heart Failure with Reduced Ejection Fraction) is the most prevalent type of heart filure. It results in a decreased volume of blood being pumped from the ventricle. The aortic arch and carotid sinuses have baroreceptors that detect reduced blood pressure, triggering the sympathetic nervous system (SNS) to release epinephrine and norepinephrine. Initially, this response aims to boost heart rate and...
15