相关实验视频

Updated: Jul 16, 2025

An Adoptive Transfer Model of Rheumatoid Arthritis in Mice
07:37

An Adoptive Transfer Model of Rheumatoid Arthritis in Mice

Published on: June 6, 2025

188

在风湿性关节炎的SKG小鼠模型中,B淋巴细胞发育的失调

Joo Eun June Kim1,2, Lin Tze Tung1,2, Roselyn R Jiang1,2

  • 1Department of Physiology, McGill University, Montreal, Quebec, Canada.

Immunology
|September 9, 2023
PubMed
概括

类风湿性关节炎严重影响小鼠的B淋巴细胞发育,导致骨髓中早期B细胞前体的显著减少,这是由于增殖受损. 这表明B细胞发育在类风湿性关节炎的发病过程中起着关键作用.

关键词:
B细胞的发育过程关节炎是一种关节炎.鼠标模型 鼠标模型在pre-B细胞中.系统性炎症 系统性炎症

更多相关视频

The bm12 Inducible Model of Systemic Lupus Erythematosus SLE in C57BL/6 Mice12:04

The bm12 Inducible Model of Systemic Lupus Erythematosus SLE in C57BL/6 Mice

Published on: November 1, 2015

17.7K
Retroviral Overexpression of CXCR4 on Murine B-1a Cells and Adoptive Transfer for Targeted B-1a Cell Migration to the Bone Marrow and IgM Production08:22

Retroviral Overexpression of CXCR4 on Murine B-1a Cells and Adoptive Transfer for Targeted B-1a Cell Migration to the Bone Marrow and IgM Production

Published on: May 31, 2020

5.1K

相关概念视频

T Cell Types and Functions01:24

T Cell Types and Functions

When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
1.1K
Receptor Downregulation in MVBs01:15

Receptor Downregulation in MVBs

Multivesicular bodies (MVBs) are mature endosomes that sort ubiquitinated proteins and then fuse with lysosomes to degrade the sorted proteins. Epidermal growth factor (EGF) and its receptor (EGFR) form a complex that can be internalized through endocytosis, sorted into an MVB, and later degraded.
The EGFR can initiate signaling pathways that  lead to cell proliferation, migration, and differentiation. Overexpression of EGFR  stimulates cells to proliferate. Excessive  EGFR...
2.1K