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分子和环境因素导致状细胞病的神经复杂症

Kristine A Karkoska¹, Jahnavi Gollamudi¹, Hyacinth I Hyacinth²

¹Division of Hematology & Oncology, Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, OH 45219-0525, USA.

Experimental biology and medicine (Maywood, N.J.)

|September 9, 2023

概括

状细胞疾病 (SCD) 由于状红细胞导致严重的神经问题. 本综述探讨了生物和环境因素,以及用于SCD患者神经保护的输血和基尿素等疗法.

科学领域:

血液学血液学血液学
神经学神经学
遗传学是一个遗传学.

背景情况:

状细胞疾病 (SCD) 是一种遗传性血液疾病,导致红细胞在缺氧下状.
这导致慢性溶血性贫血,血管封闭和广泛的器官损伤,包括大脑.
在SCD中神经复杂症的范围从中风到认知缺陷,即使没有明显的脑损伤.

研究的目的:

审查SCD中神经系统并发症的生物学和社会环境因素.
讨论现有的疾病修饰疗法的神经保护作用.
为突出新兴的SCD相关的神经问题实验性疗法.

主要方法:

关于生物机制的文献综述.
对影响SCD神经学的社会环境因素的分析.
对治疗干预措施的证据评估.

主要成果:

与SCD相关的神经损伤源于血管封闭,低氧化和神经炎症.
输血和氧尿素显示出神经保护的潜力.
目前正在研究针对性神经保护的几种新疗法.

结论:

神经复杂症是SCD的主要负担,受到生物和环境因素的影响.
目前的疗法提供了一些神经保护,但缺口仍然存在.
对向治疗的进一步研究对于管理与SCD相关的脑损伤至关重要.

关键词:

状细胞疾病是一种状细胞疾病.认知能力下降认知能力下降血液溶解性贫血是什么意思低氧症的低氧症是什么神经炎症是一种神经炎症.血管病变是一种血管病变.

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