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在烧伤患者内静脉推送塞费皮姆的药理学分析,患者的脏清除增加

David M Hill¹, Bing Yang², S Casey Laizure²

¹Department of Pharmacy, Regional One Health, 877 Jefferson Avenue, Memphis, TN 38103, USA.

Journal of burn care & research : official publication of the American Burn Association

|September 9, 2023

概括

患有增强干净度 (ARC) 的患者可能无法在标准的静脉注射推送剂量下达到足够的塞费皮姆水平. 修改后每4小时服用1克的疗法可以增强cefepime的效果.

科学领域:

药理学药理学是指药理学的学科.
临界护理医学临界护理医学
腎臟病學 (nephrology) 是一種醫學專業.

背景情况:

增加清除 (ARC) 在重症患者中很常见,导致药物消除的增加.
由于脏清除速度快,在ARC患者中,标准cefepime剂量可能不足.
内静脉推送 (IVP) 管理可以进一步损害药物度.

研究的目的:

评估Cefepime的药理动力学目标在患有ARC的重症患者中的实现.
为了比较cefepime的剂量方案,以优化ARC患者的杀菌活性.

主要方法:

在ARC的十名受试者中对塞费皮姆的药理动力学分析.
用于药物度测量的LC-MS/MS.
种群药动力学建模和模拟以比较剂量策略.

主要成果:

标准的2g每8小时IVP cefepime疗法实现了低于最佳的目标.
模拟显示,每4小时1克的治疗方案显著改善了最低抑制度 (MIC) 以上的时间.
每4小时服用1克的疗法,在剂量间隔的92-100%内保持度高于MIC断点.

结论:

目前的cefepime IVP疗法可能不适合ARC患者.
每4小时服用1克cefepime是一种切实可行的策略,以确保ARC患者的杀菌活性.
优化cefepime剂量对于治疗危急病患者的有效治疗至关重要.

关键词:

抗生素抗生素是一种抗生素.贝塔乳糖是一种β乳糖.烧伤,烧伤,烧伤就是一个问题.这是一个很快的时间.药理动力学是药理动力学的一个方面.药物动力学药物动力学

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