在自闭症谱系障碍的口语句子处理过程中,大脑-小脑功能连接模式更强和更弱
Jussi Alho1,2, John G Samuelsson2,3, Sheraz Khan1,2,4
1Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Human brain mapping
|September 9, 2023
概括
自闭症谱系障碍 (ASD) 儿童在小脑中表现出异常的大脑对言语的反应,影响语言处理. 在ASD中大脑小区的差异可能源于注意力和听觉预测的改变.
科学领域:
- 神经科学是一个神经科学.
- 发展心理学 发展心理学
- 语音和语言病理学 语言病理学
背景情况:
- 大脑小区的差异在自闭症谱系障碍 (ASD) 中很常见.
- 这些小脑区别对ASD语言处理的影响尚不清楚.
研究的目的:
- 调查ASD儿童在语言处理过程中的小脑活动和连接性与典型发育 (TD) 儿童相比如何不同.
- 探索非典型小脑功能,自闭症严重程度和注意力之间的关系.
主要方法:
- 磁脑电图 (MEG) 用于记录ASD和TD儿童的大脑活动.
- 孩子们被动地倾听有意义的英语和无意义的Jabberwocky句子.
- 应用了一种新的高分辨率源定位技术来分析小脑活动.
主要成果:
- 与TD儿童不同的是,ASD儿童在右小脑叶VI中没有表现出有意义和无意义句子之间的唤起反应的差异.
- 自闭症儿童在右小脑叶VI和语言/感官运动区域之间表现出不典型的功能连接.
- 在ASD中异常连接与ASD严重程度和注意抑制相关,在早期时间窗口中与听觉皮层的连接更强.
结论:
- 在ASD中,大脑小脑语言处理的特点是异常的功能连接性和对有意义和无意义语言的改变反应.
- 这些发现表明,ASD中的脑小脑语音机制受到异常刺激驱动的注意力的影响,可能是由于非典型的时间处理和听觉预测.
- 小脑在语言处理和ASD注意力方面的作用需要进一步研究.
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