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Updated: Jul 16, 2025

Defining Gene Functions in Tumorigenesis by Ex vivo Ablation of Floxed Alleles in Malignant Peripheral Nerve Sheath Tumor Cells
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Defining Gene Functions in Tumorigenesis by Ex vivo Ablation of Floxed Alleles in Malignant Peripheral Nerve Sheath Tumor Cells

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在神经母细胞瘤中,BARD1生殖系变异诱导了哈普隆缺陷和DNA修复缺陷

Michael P Randall1, Laura E Egolf1,2, Zalman Vaksman1,3

  • 1Division of Oncology and Center for Childhood Cancer Research, Children's Hospital of Philadelphia, Philadelphia, PA, USA.

Journal of the National Cancer Institute
|September 9, 2023
PubMed
概括

生殖系BARD1变种损害了DNA修复,增加了神经母细胞瘤的风险. 这一发现为这种侵袭性儿童癌症提供了新的治疗点.

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