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对病毒相关的肺部阿斯伯吉洛症进行临床检测

Robina Aerts^1,2, Brice Autier^3,4, Maximilian Gornicec⁵

¹Department of Internal Medicine, University Hospitals Leuven, Leuven, Belgium.

Expert review of molecular diagnostics

|September 9, 2023

概括

照顾点的测试,如阿斯伯吉illus galactomannan 侧流量测试,显示出早期诊断病毒相关的肺阿斯伯吉洛症 (VAPA) 在重症患者的承诺,潜在地改善了结果.

科学领域:

医学真菌学医学真菌学
传染性疾病传染性疾病
临界护理医学临界护理医学

背景情况:

严重的呼吸道病毒感染,包括SARS-CoV-2和流感,在重症患者中增加了与病毒相关的肺炎 (VAPA) 的风险.
延迟诊断VAPA与较高的死亡率有关.
护理点测试 (POCT) 提供了早期VAPA检测和改善患者预后的潜力.

研究的目的:

审查诊断VAPA的临床检测的表现.
在呼吸和血液样本中分析POCT的疗效.
为VAPA提供最新的新兴诊断工具.

主要方法:

对VAPA的临床检测现有文献的审查.
对基于银河素的横向流量试验 (LFA) 的性能数据的分析.
将LFA性能与传统的ELISA方法进行比较.

主要成果:

IMMY Aspergillus 银河甘南侧流测定 (LFA) 显示了与银河甘南 ELISA 用于 VAPA 诊断的性能相似的性能.
大多数对VAPA的POCT评估都集中在COVID-19患者身上,对流感患者的数据有限.
在呼吸道样本 (特别是支气管支气管洗液) 中,LFA显示出有希望的结果,用于早期诊断COVID-19相关的肺阿斯伯吉洛症 (CAPA).

结论:

临床检测,特别是LFA,对于早期诊断VAPA具有重大潜力.
需要进一步的研究来评估POCT在流感相关的VAPA中的表现.
血清LFA测试在早期VAPA诊断中可能不那么有效,除非在某些特定情况下,如侵入性气管支气管支气管阿斯伯吉洛症.

关键词:

亚斯珀吉洛斯 (Aspergillus) 是一种植物.在这里,我们可以看到COVID COVID COVID.在ICU中,医生会对患者进行治疗.侧流装置测试试验侧流装置测试流感流感流感流感流感侧向流量检测试验没有非中性增殖的作用.肺部阿斯伯吉洛斯症 (aspergillosis) 是一种肺部疾病.

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