系统性炎症,神经炎症和外科期间的神经认知障碍
Shilin Jia1,2, Hui Yang2, Fang Huang2
1Department of Anesthesiology, Hospital of Stomatology, Guanghua School of Stomatology, Sun Yat-Sen University, 74 Zhongshan Rd 2, Guangzhou, 510080, China.
概括
经手术期神经认知障碍 (PND) 与系统性炎症有关. 这篇评论探讨了炎症如何导致脑损伤以及PND的潜在治疗方法.
科学领域:
- 神经科学是一个神经科学.
- 麻醉学 麻醉学
- 老年病的医生 老年病的医生
背景情况:
- 术后神经认知障碍 (PND) 是手术后的常见并发症,特别是在老年患者中.
- 确切的PND原因尚不清楚,但系统性炎症越来越被认为是关键因素.
- 现有研究提出了相互矛盾的数据,需要对当前证据进行全面审查.
研究的目的:
- 综合最近关于外科手术期间系统性炎症在PND发病过程中的作用的证据.
- 阐明炎症介导神经炎症和脑损伤的机制.
- 探索基于理解炎症调节的PND潜在的治疗策略.
主要方法:
- 使用PubMed数据库进行了系统的文献审查.
- 搜索术语包括"妄想"",术后认知功能障碍"",术后神经认知障碍"",炎症"和"系统性".
- 选择并分析了对该主题做出重大贡献的全文英语文章.
主要成果:
- 外科手术期间的全身炎症在PND的发展中起着重要作用.
- 炎症可以调解神经炎症和随后的脑损伤.
- 了解炎症途径为PND预防和治疗提供了目标.
结论:
- 系统性炎症是PND发展的关键调解者.
- 对炎症调节的进一步研究对于开发有效的PND干预措施至关重要.
- 将有关炎症机制的发现转化为临床实践可能会改善PND的结果.
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