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暴露和不健康的衰老:从空气污染到职业暴露的环境驱动因素

Tamas Pandics^1,2,3, David Major¹, Vince Fazekas-Pongor¹

¹Department of Public Health, Faculty of Medicine, Semmelweis University, Budapest, Hungary.

|September 9, 2023

概括

环境暴露显著加速衰老,并增加心血管和脑疾病的风险,如阿尔茨海默氏症和中风. 减少环境毒素是促进健康老龄化和预防这些疾病的关键.

科学领域:

环境健康环境健康
老年学是一门学科.
神经科学是一个神经科学.

背景情况:

全球人口老龄化正面临与年龄相关的非传染性疾病的增长率,特别是影响心血管和大脑健康.
暴露组,包括所有环境暴露,显著影响衰老过程和疾病的发展.
衰老本身是许多慢性疾病的主要危险因素,包括神经退行性疾病和心血管疾病.

研究的目的:

审查暴露基对不健康的衰老和与年龄相关的疾病的影响.
探索环境因素如何加速衰老,增加生物年龄,并导致心血管和大脑病理.
突出环境毒素在神经退行性疾病,血管认知障碍 (VCI) 和痴呆症中的作用.

主要方法:

关于环境暴露和衰老的研究的综合文献综述.
对细胞和分子机制的分析,这些机制将衰老,环境因素和疾病的发病机制联系起来.
确定特定的环境毒素及其对心血管和中枢神经系统的影响.

主要成果:

环境因素加速衰老,增加生物年龄,并促进与年龄相关的疾病.
特定的有毒物质 (颗粒物,农药,重金属) 导致心血管和大脑衰老疾病.
有毒物质会导致血管损伤,穿越血脑屏障,诱导神经炎症和神经元功能障碍.

结论:

环境因素极大地调节心血管和大脑的衰老.
了解有毒物质如何加剧衰老对于制定预防策略至关重要.
减轻环境暴露对于促进健康老龄化和减少与年龄有关的疾病负担至关重要.

关键词:

加快衰老的加速衰老.衰老的衰老衰老的衰老生物年龄生物年龄环境污染环境污染暴露组体是指暴露组体.毒理学毒理学毒理学

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