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在突尼斯人口中,TLR2-1-6的多态性和双相情感障碍之间的关联

Youssef Aflouk¹, Oumaima Inoubli², Amira Kenz²

¹Laboratory of Genetics, Biodiversity, and Valorization of Bioresources GBVB (LR11ES41), Higher Institute of Biotechnology of Monastir (ISBM), University of Monastir, Monastir, 5000, Tunisia. afloukyoussef1@gmail.com.

Molecular biology reports

|September 9, 2023

概括

收费类受体 (TLR) 的遗传变异与双相情感障碍 (BD) 有关. 某些TLR2和TLR6多态可能会保护女性免受BD,而TLR2和TLR1变异会增加BD风险,特别是在女性中.

科学领域:

免疫遗传学免疫遗传学
神经精神病学是一种神经精神病学.

背景情况:

双极性障碍 (BD) 与免疫失调有关.
异常的托尔类受体2-1/6 (TLR2-1/6) 介导的炎症反应与BD有关.
遗传因素对BD倾向的贡献仍然不清楚.

研究的目的:

调查TLR2,TLR1和TLR6的功能多态化与双相情感障碍 (BD) 的倾向之间的联系.

主要方法:

使用PCR-RFLP对292名对照和131名突尼斯人BD患者进行TLR2,TLR1和TLR6多态的基因定型.
对BD的多态性和单种类型关联的分析.
二元逻辑回归用于关联分析.

主要成果:

在健康的女性中,TLR2-196-174Ins/Del和TLR6-S249P小等位基因的频率更高,这表明它们具有保护作用.
在BD患者中,TLR2-R677W (CT+TT基因型和T等位基因) 和TLR1-R80T (GC+CC基因型和C等位基因) 频率显著更高,表明风险增加.
在BD患者中,特定的单元类型 (InsGTCGT和delGCCGT) 显著过多.

结论:

TLR2-196-174Ins/Del和TLR6-S249P可能是女性BD的保护因素.
TLR2-R677W和TLR1-R80T与BD的风险增加密切相关.
TLR2-R677W可能作为女性BD的遗传标志物,需要在更大的队列中进一步调查.

关键词:

双极性障碍是一种双极性障碍.多态性多态性多态性在TLR1中,在TLR2中,它是TLR2.在TLR6中,

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