尿中新素和生物素表明,炎症在自闭症谱系障碍中起作用
Ece Oge-Enver1, Esra Isat1, Mehmet Serif Cansever2
1Cerrahpasa Medical Faculty, Department of Pediatrics, Division of Nutrition and Metabolism, Istanbul University-Cerrahpasa, Istanbul, Turkey.
Metabolic brain disease
|September 9, 2023
概括
在患有自闭症谱系障碍 (ASD) 的人群中,尿中新素 (NE) 和生物素 (BIO) 水平,即炎症指标,显著更高. 这些发现表明,NE/BIO和NE/CRE比率可能作为ASD免疫激活的生物标志物.
科学领域:
- 生物化学 生物化学
- 免疫学 免疫学 免疫学
- 神经科学是一个神经科学.
背景情况:
- 炎症与自闭症谱系障碍 (ASD) 的病原发生有关.
- 二胺代谢物,如二胺 (NE) 和生物二胺 (BIO),是免疫系统激活和炎症的生物标志物.
- 研究这些代谢物可能会为ASD的生物学基础提供见解.
研究的目的:
- 在患有ASD的个体中检查尿中丁代谢物水平 (NE和BIO).
- 评估这些代谢物作为ASD免疫激活和炎症的生物标志物的潜力.
- 探索NE,BIO和肌素 (CRE) 比率与ASD诊断之间的关系.
主要方法:
- 一项观察性,横截面,前性研究,涉及212名自闭症患者和68名健康对照.
- 用高性能液态染色学分析尿液样本以检测内素 (NE) 和生物素 (BIO) 度.
- 测量标准化使用肌素 (CRE) 比率 (NE/CRE,BIO/CRE),并计算NE/BIO比率. 没有包括患有慢性疾病或活跃感染的人.
主要成果:
- 与对照人群相比,ASD患者的尿内NE/CRE和NE/BIO比率显著增加.
- 无论是NE/CRE和NE/BIO比率,都显示出ASD患者和对照人群之间的显著区分能力 (AUC分别为0.756和0.717).
- 这些发现表明ASD病理生理学中的炎症增加和T细胞介导免疫力.
结论:
- 尿中NE/CRE和NE/BIO比率升高表明在ASD中炎症和T细胞介导免疫力起作用.
- NE/BIO比率显示出作为诊断炎症标志物的潜力,用于识别ASD病变发生过程中的免疫激活.
- 需要进一步的研究来验证这些发现,并探索治疗影响.
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