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卵泡液中的微生物存在与试管婴儿结果之间的关联:系统性审查和元分析

Shanshan Ou¹, Ming Liao¹, Lanyu Cui²

¹Center of Reproductive Medicine, The First Affiliated Hospital of Guangxi Medical University, No. 6 Shuangyong Road, Qingxiu District, Nanning, 530021, Guangxi, China.

Journal of assisted reproduction and genetics

|September 9, 2023

概括

在不育妇女的雌性 (FF) 中微生物的存在会对结果产生负面影响,降低怀孕率. 然而,这些比例仍然相似,这表明特定物种可能会影响成功.

科学领域:

生殖医学生殖医学
微生物学微生物学
在体外受精过程中受精.

背景情况:

女性 (FF) 中微生物的存在越来越被认为是影响不育妇女结果的潜在因素.
了解FF中微生物的特定影响对于提高治疗效率至关重要.

研究的目的:

系统地综合现有关于微生物存在于不孕妇女的FF对结果的影响的研究.
调查FF中微生物检测与怀孕和受精率等关键指标之间的关联.

主要方法:

从2022年1月到2023年7月,在主要数据库 (PubMed,Cochrane,Embase,Web of Science,Clinicaltrials.gov) 进行了系统的文献搜索.
来自确定FF中微生物存在的研究数据使用RevMan 5.4软件进行了分析,并对阴道污染进行了调整.
方法包括微生物培养,鉴定,ELISA和干扰素玛释放试验 (IPA).

主要成果:

在检测污染后,在289名妇女身上确认了FF中的微生物检测.
与FF-负组 (32.2%) 相比,FF-阳性组的怀孕率明显较低 (19.7%).
在FF-阳性 (60.0%) 和FF-阴性 (62.0%) 组之间,受精率是可比的,证据质量非常低.

结论:

在FF中的不同微生物物种可能对结果产生不同的影响.
乳酸菌种可能具有有益的影响,而其他微生物可能会对成功产生负面影响.
需要进一步进行高质量的研究,以阐明不同微生物在FF中的特定作用及其对结果的确切影响.

关键词:

毛囊液是什么? 毛囊液是什么?试管婴儿的结果进行元分析分析.微生物群中的微生物群.系统性审查系统性审查

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