环氧德克斯复合物形成对每个药物的溶解性变化的影响,这是由于酸性NSAIDs和基本H2阻断剂之间的分子间相互作用造成的
Chihiro Tsunoda1, Kanji Hasegawa1, Ryosuke Hiroshige1
1Faculty of Pharmaceutical Sciences, Tokyo University of Science, 2641 Yamazaki, Noda, Chiba 278-8510, Japan.
Molecular pharmaceutics
|September 9, 2023
概括
环极素 (CD) 在组合中增强了药物的溶解性. β-cyclodextrin (β-CD) 提高了某些药物混合物的溶解性和其他药物的溶解率,即使与药物相互作用.
科学领域:
- 制药科学 制药科学
- 物理化学 物理化学
背景情况:
- 环极素 (CDs) 广泛用于提高水溶性较差的药物的溶性.
- 关于CD如何影响多种相互作用药物存在时的药物溶解度的研究有限.
研究的目的:
- 为了研究β-cyclodextrin (β-CD) 对单个药物在多种药物组合中的溶解性的影响.
- 了解β-CD如何影响药物相互作用发生时的药物溶解性.
主要方法:
- 使用的酸性药物 (英多梅他辛,迪克洛菲纳克) 和基本药物 (法莫蒂丁,齐米蒂丁) 或类似的化合物 (伊米达,希斯蒂丁,阿尔金因).
- 评估β-CD在各种组合中对药物溶解性的影响,包括那些形成优菌混合物和那些已知相互作用的组合.
主要成果:
- 印米他辛和迪克洛菲纳克与某些基本化合物形成了优化混合物,增加了它们的内在溶解度和β-CD亲和力.
- 添加β-CD在二二二组合中提高了famotidine的溶解度,抵消了因相互作用而导致的溶解度下降.
结论:
- 在某些药物组合中,β-CD表现出协同效应,增强溶解性.
- β-CD有效地提高了药物组合的溶解率,其中相互作用降低了溶解度,如 famotidine-diclofenac.
- β-CD可以优化药物的物理化学特性,即使在复杂的,相互作用的多药配方中.
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