在生殖年龄的男性中暴露于帕拉本和精液质量
Xiaoli Shen1, Ming Zhan2, Yuqing Wang3
1Ministry of Education-Shanghai Key Laboratory of Children's Environmental Health, School of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Ministry of Education-Shanghai Key Laboratory of Children's Environmental Health, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Ecotoxicology and environmental safety
|September 9, 2023
概括
暴露于个人护理产品中常见的类混合物,与男性的精子度,精子总数和运动率的降低有关. 丁甲 (BuP) 和甲甲 (MeP) 是这些影响的关键因素.
科学领域:
- 环境健康 环境健康
- 生殖毒理学 生殖毒理学
- 流行病学 流行病学
背景情况:
- 烯是消费品中广泛使用的防腐剂.
- 动物研究表明雄性生殖毒性,但人类流行病学数据不一致.
- 对烯混合物对男性生殖健康的影响的研究是有限的.
研究的目的:
- 为了研究个人和混合物暴露和精液质量参数之间的关联.
- 评估常见的对男性生育指标的影响.
主要方法:
- 对795名男性的尿样进行了分析,分析了六种类甲的度 (MeP,EtP,PrP,BuP,BzP,HeP).
- 利用多重线性回归和加权量子式总和 (WQS) 回归模型.
- 评估了对暴露和精液质量参数之间的关系.
主要成果:
- 暴露于帕拉本混合物与精子度,精子总数和渐进性运动率的下降显著相关.
- 丁甲 (BuP) 是减少精子度和数量的主要贡献者.
- 甲基 (MeP) 被确定为减少渐进性运动性的主要贡献者.
结论:
- 结果表明,在男性中,烯混合物暴露与精液质量的关键参数之间存在负面关联.
- 这些发现突显了在生育年龄的男性中,类混合物对生殖的潜在风险.
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