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相关概念视频

Stem Cell Therapy for Tissue Regeneration01:21

Stem Cell Therapy for Tissue Regeneration

4.1K
Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell...
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Stem Cell Culture01:17

Stem Cell Culture

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Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...
5.2K
iPS Cell Differentiation01:22

iPS Cell Differentiation

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The ability of induced pluripotent stem cells or iPSCs to differentiate into most body cell types has stimulated repair and regenerative medicine research over the past few decades. iPSC-derived blood cells, hepatocytes, beta islet cells, cardiomyocytes, neurons, and other cell types can repair injuries or regenerate damaged tissue in diseases such as diabetes and neurodegenerative disorders.
2.7K
Mesenchymal Stem Cells01:19

Mesenchymal Stem Cells

4.8K
Mesenchymal stem cells (MSCs) are adult stem cells that can differentiate into most connective tissue cell types, except for hematopoietic cells, depending upon the source of MSCs. For example, bone-marrow-derived MSCs (BM-MSCs) can differentiate into osteocytes, hepatocytes, and pancreatic and neuronal cells. MSCs can be isolated from various sources such as bone marrow, placenta, adipose tissue, teeth, and Wharton’s jelly, a gelatinous substance in the umbilical cord. The ease of their...
4.8K
Induced Pluripotent Stem Cells01:06

Induced Pluripotent Stem Cells

4.1K
Stem cells are undifferentiated cells that divide and produce different cell types. Ordinarily, cells that have differentiated into a specific cell type are terminally differentiated; however, scientists have found a way to reprogram these mature cells so that they dedifferentiate and return to an unspecialized, proliferative state. These cells are pluripotent like embryonic stem cells—able to produce all cell types—and are called induced pluripotent stem cells (iPSCs).
Somatic...
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Embryonic Stem Cells00:57

Embryonic Stem Cells

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Embryonic stem (ES) cells were first discovered in mice in 1981 by Martin Evans. In 1998, James Thomson identified a method to isolate embryonic stem cells from humans. Human embryonic stem cells (hESCs) are obtained from 3-5 day old embryos that remain unused after an in vitro fertilization procedure.
ES cells are grown in a culture medium where they can divide indefinitely, creating ES cell lines. Under certain conditions, ES cells can differentiate, either spontaneously into a variety of...
3.6K

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相关实验视频

Updated: Jul 16, 2025

Generation of Multivirus-specific T Cells to Prevent/treat Viral Infections after Allogeneic Hematopoietic Stem Cell Transplant
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Generation of Multivirus-specific T Cells to Prevent/treat Viral Infections after Allogeneic Hematopoietic Stem Cell Transplant

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针对COVID-19的基于干细胞的疗法.

Xiaomei Chen1, Bowen Liu1, Chao Li1

  • 1Department of Hematology, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, Guangdong 510080, PR China.

International immunopharmacology
|September 9, 2023
PubMed
概括

干细胞疗法在治疗COVID-19造成的肺损伤方面表现有前途,并可能作为一种新型疫苗. 这篇评论探讨了干细胞机制,临床试验和用于预防COVID-19的工程外细胞囊泡.

关键词:
在 COVID-19 疫情中,基于细胞的治疗方法临床试验中的临床试验.细胞外囊泡 细胞外囊泡介质细胞干细胞 介质细胞干细胞疫苗 疫苗是一种疫苗.

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科学领域:

  • 免疫学 免疫学 免疫学
  • 再生医学是一种再生医学.
  • 病毒学 病毒学

背景情况:

  • 尽管COVID-19不再是全球卫生紧急情况,但由于再感染和新兴变种,它仍然存在风险.
  • 由于COVID-19引起的肺部并发症,需要对有效的治疗方法和预防策略进行持续的研究.

研究的目的:

  • 系统地审查针对COVID-19的基于干细胞的疗法.
  • 探索工程外细胞囊泡作为COVID-19疫苗的潜力.
  • 总结COVID-19中干细胞治疗的病理生理过程和机制.

主要方法:

  • 对现有文献进行系统审查.
  • 对涉及干细胞的注册COVID-19临床试验的分析.
  • 对干细胞衍生物和细胞外囊泡的临床前和临床数据的评估.

主要成果:

  • 干细胞衍生物在临床前和临床研究中显示出治疗COVID-19相关肺部问题的潜力.
  • 工程外细胞囊泡正在作为一种新型疫苗方法来预防COVID-19进行研究.

结论:

  • 基于干细胞的方法为COVID-19肺部损伤提供了有希望的治疗途径.
  • 对细胞外囊泡的进一步研究可能会导致针对COVID-19的创新疫苗策略.