结构性决定因素和心脏代谢类型学与社区老年人的脆弱性有关
Shamatree Shakya1, Susan G Silva2, Eleanor S McConnell3
1College of Nursing, University of Illinois at Chicago, Chicago, IL, United States.
Archives of gerontology and geriatrics
|September 9, 2023
概括
在老年人中识别出不同的心脏代谢特征对于预防虚弱至关重要. 胰岛素耐药小组显示出明显更高的脆弱风险,强调了针对性干预的必要性.
科学领域:
- 老年学是一门学科.
- 心脏病学 心脏病学
- 公共卫生 公共卫生
背景情况:
- 虚弱是一种严重的老年综合征,与不良健康结果有关.
- 已知心脏代谢风险因素有助于虚弱,但它们的特定组合 (类型) 和关联仍未得到充分探索.
研究的目的:
- 在老年人中识别出不同的心脏代谢亚组.
- 检查这些子组,结构决定因素和脆弱性之间的关系.
- 为制定针对脆弱性预防和延迟的量身定制干预措施提供信息.
主要方法:
- 从健康和退休研究 (2006-2008) 中对7984名社区居住的老年人 (65岁以上) 进行横截面研究.
- 隐性类分析利用七个心脏代谢指标来定义子组.
- 后勤回归分析了结构决定因素,心脏代谢类型学和脆弱性 (由≥3个特征定义) 之间的关联.
主要成果:
- 确定了三个不同的心脏代谢子组:胰岛素耐药 (n=3547),高血压性脂质失调 (n=1246),高血压 (n=3191).
- 胰岛素抵抗性亚组的特点是女性,非西班牙裔黑人和受教育程度较低的人群的患病率较高,其脆弱性风险增加了一倍 (aOR=2.0).
- 在女性,少数民族和受教育程度较低的人群中,脆弱性风险也较高.
结论:
- 在老年人中存在不同的心脏代谢类型,胰岛素耐药特征构成最大的脆弱风险.
- 性别,种族/种族和教育等社会人口因素与心脏代谢类型和脆弱性都有显著的关联.
- 针对特定心脏代谢特征的量身定制干预措施对于有效的脆弱性预防和管理至关重要.
更多相关视频
04:00Author Spotlight: Assessing Surgical Frailty with Point-of-Care Ultrasound of Quadriceps Muscles
Published on: July 26, 2024
575
09:40Phosphorus-31 Magnetic Resonance Spectroscopy: A Tool for Measuring In Vivo Mitochondrial Oxidative Phosphorylation Capacity in Human Skeletal Muscle
Published on: January 19, 2017
11.8K
相关概念视频
01:30Coronary Artery Disease I: Introduction
20
Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
20
01:27Heart Failure I: Introduction
14
Heart failure refers to a clinical syndrome caused by structural or functional cardiac disorders that prevent the heart from pumping an adequate amount of blood to meet the body's metabolic needs. This condition often arises from myocardial infarction or ischemia, leading to decreased cardiac output, reduced tissue perfusion, impaired gas exchange, fluid volume imbalance, and decreased functional ability.Heart failure can result from disruptions in the mechanisms that regulate cardiac output...
14
01:30Heart Failure IV: Classification and Diagnostic Evaluation
19
Heart failure can be classified in various ways, with the most common classifications based on physical activity limitations, disease progression, severity, and treatment strategies.The Functional Classification of Heart Failure divides patients into four categories based on physical activity limitation due to symptom burden.Class I: Patients in this class have cardiac disease but no physical activity limitations. Ordinary activities like walking, climbing stairs, or routine tasks do not cause...
19
01:25Cardiomyopathy I: Introduction and Classification
15
Cardiomyopathy, or CMP, is a group of diseases affecting the myocardial structure, impairing its ability to pump blood effectively. This condition can lead to arrhythmias, heart failure, or sudden cardiac death.Cardiomyopathies are classified into primary and secondary categories:Primary Cardiomyopathy refers to conditions involving only the heart muscle that are often idiopathic (of unknown cause) or genetic. They primarily affect the myocardium without the involvement of other systemic...
15
01:26Aging
86
Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
86
01:17Pathophysiology of Heart Failure
1.6K
Heart failure (HF) is a progressive syndrome involving ventricles that leads to inadequate cardiac output. It can be classified based on location and output or ejection fraction. Ejection fraction (EF) is an essential measurement in the diagnosis and surveillance of HF. Reduced EF corresponds to systolic heart failure (HFrEF). However, HF with preserved ejection fraction (HFpEF) is becoming increasingly prevalent. Also known as diastolic HF, this form of HF is related to aging. The...
1.6K