在患有心脏病的患者中,功能障碍的每个阶段的无氧值的决定因素
Asami Ogura1, Kazuhiro P Izawa2, Hideto Tawa3
1Departments of Rehabilitation, Sanda City Hospital, Hyogo, Japan; Department of Public Health, Graduate School of Health Sciences, Kobe University, Hyogo, Japan; Cardiovascular Stroke Renal Project (CRP), Hyogo, Japan.
The American journal of cardiology
|September 9, 2023
概括
在心脏病患者中,无氧值 (AT) 受功能的影响. 严重的功能障碍将AT与左心室喷射分数和血红蛋白联系起来,而较轻的功能障碍则将其与端潮氧气压联系起来.
科学领域:
- 心脏病学 心脏病学
- 腎臟病學 (nephrology) 是一種醫學專業.
- 运动生理学 运动生理学
背景情况:
- 患有心脏病的患者经常表现出降低的无氧值 (AT).
- 影响这些患者AT的因素可以根据功能障碍的严重程度而有所不同.
- 了解这些决定因素对于管理患有并发性心脏和病的患者至关重要.
研究的目的:
- 在患有心脏病的患者中,研究无氧值 (AT) 在功能不同阶段的独立决定因素.
- 确定功能严重程度如何改变AT和生理参数之间的关系.
主要方法:
- 预计将招募250名心脏病患者进行心肺运动测试.
- 根据估计的淋巴膜过率 (eGFR) 将其分为三组:<45,45-59和≥60毫升/分钟/1.73米2.
- 多变量线性回归分析以确定每个eGFR组内AT的独立预测因子.
主要成果:
- 总共分析了201名患者,显示AT显著下降,功能恶化 (eGFR <45: 10.9 ± 2.1; 45-59: 12.4 ± 2.5; ≥60: 14.0 ± 2.6毫升/分钟/公斤).
- 在EGFR<45毫升/分钟/1.73米2的患者中,左心室喷射率 (LVEF) 和血红蛋白水平是AT的重要决定因素.
- 在EGFR 45-59和≥60毫升/分钟/1.73米2的患者中,从静止到AT的端潮氧部分压力 (ΔPETO2) 的变化是显著的决定因素.
结论:
- 心脏病患者无氧值 (AT) 的决定因素受到功能障碍的阶段的显著影响.
- 对于患有严重功能障碍 (eGFR <45) 的患者,LVEF和血红蛋白是影响AT的关键因素.
- 对于中度或保存功能 (eGFR 45-59和≥60) 的患者,ΔPETO2成为AT的主要决定因素.
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