季节性光时调节外围时钟和小鼠的能量代谢
Lewin Small1, Leonidas S Lundell1, Jo Iversen1
1Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Cell metabolism
|September 9, 2023
概括
季节性光线变化通过改变食物摄入时间来影响能量代谢. 冬季光周期增强脂质代谢节奏,减少脂肪质量,并影响肝脏的甘油三,独立于黑激素的信号传递.
科学领域:
- 时间生物学 时间生物学
- 代谢生理学 代谢生理学
- 环境科学 环境科学
背景情况:
- 循环节律调节能量代谢.
- 在赤道地区以外,季节性光变化显著.
- 当前的研究经常忽视季节性光周期,使用赤道光周期.
研究的目的:
- 研究季节性光周期的变化如何影响外围时钟和能量恒温.
- 为了确定季节性光线变化在代谢调节中的作用.
- 探索光周期,昼夜节律和能量平衡之间的相互作用.
主要方法:
- 鼠标被暴露在模拟的夏季,冬季和赤道光周期中.
- 评估了周围组织时钟和能量代谢标记物的节律性.
- 他们比较了富含黑色素和缺乏黑色素的小鼠.
主要成果:
- 冬季光周期增加了节律性脂质代谢的幅度.
- 冬季光周期中的小鼠显示脂肪质量和肝脏甘油三酸减少.
- 季节性光线对能量代谢的影响主要是由食物摄入时间调节的,而不是黑激素水平.
结论:
- 季节性光线持续时间显著影响能量代谢和周围生理时钟功能.
- 改变光周期可以调节脂质代谢和身体成分.
- 食物摄入的时间受季节性光线的影响,是能量恒温的关键因素.
相关概念视频
02:19Circadian Rhythms and Gene Regulation
4.1K
The biological clock is involved in many aspects of regulating complex physiology in all animals. It was in 1935 when German zoologists, Hans Kalmus and Erwin Bünning, discovered the existence of circadian rhythm in Drosophila melanogaster. However, the internal molecular mechanisms behind the circadian clock remained a mystery until 1984, when Jeffrey C. Hall, Michael Rosbash, and Michael W. Young discovered the expression of the Per gene oscillating over a 24-hour cycle. In subsequent...
4.1K
02:45Biological Clocks and Seasonal Responses
34.7K
The circadian—or biological—clock is an intrinsic, timekeeping, molecular mechanism that allows plants to coordinate physiological activities over 24-hour cycles called circadian rhythms. Photoperiodism is a collective term for the biological responses of plants to variations in the relative lengths of dark and light periods. The period of light-exposure is called the photoperiod.
34.7K