雷丁醇棕酸在治疗慢性史蒂文 - 约翰逊综合征与眼皮表面角质化
Ananya Parampalli Ravindra1, Rajesh Sinha1, Aafreen Bari1
1Cornea, Cataract & Refractive Surgery Services, Dr Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, 110029, India.
The ocular surface
|September 9, 2023
概括
在慢性史蒂文斯-约翰逊综合征患者的眼表面角质化显著改善. 这种治疗促进了杯状细胞的发展,提供了安全有效的治疗选择.
科学领域:
- 眼科医生 眼科 眼科
- 再生医学是一种再生医学.
- 皮肤病学 皮肤病学
背景情况:
- 慢性史蒂文斯-约翰逊综合征 (SJS) 经常导致眼睛表面并发症,包括角质化.
- 在SJS中,眼表面角质化显著损害视力和生活质量.
研究的目的:
- 评估局部Retinol Palmitate眼科溶液在慢性SJS患者眼表面角质化管理中的疗效.
- 评估雷丁醇棕酸对膜参数和杯状细胞存在的影响.
主要方法:
- 在12周内进行了一项比较性干预研究.
- 结果使用施尔默-1测试,ASOCT撕裂镜高度,孟加拉染色,印象细胞学和OSDI问卷进行了评估.
- 患者接受了常规治疗,有或没有局部雷丁醇棕酸盐.
主要成果:
- 局部雷丁醇棕酸显著改善了Schirmer-1测试,撕裂镜高度,并减少了角膜/结膜孟加拉染.
- 观察到显著减少眼表面角质化和改善主观得分 (OSDI).
- 玻璃杯细胞在1周内出现,在Retinol Palmitate组1个月后增加,尽管它们的存活时间有限.
结论:
- 局部雷丁醇棕酸是一种安全有效的治疗慢性SJS眼皮表面角质化.
- 该药物在逆转角质化和促进杯状细胞再生方面表现出潜力.
- 虽然有益,但诱导杯细胞的长期存活需要进一步研究.
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