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慢性寒冷环境通过调节肠道微生物群衍生胆酸来调节类风湿性关节炎
Juan Liu1, Fu Peng2, Hao Cheng3
1State Key Laboratory of Southwestern Chinese Medicine Resources, School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China; Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu 610072, China.
暴露于寒冷会通过改变肠道细菌和胆汁酸来恶化类风湿性关节炎 (RA). 补充taurohyodeoxycholic acid (THDCA) 可以减轻这些影响,为与感冒相关的RA提供新的治疗途径.
科学领域:
- 免疫学 免疫学 免疫学
- 微生物学 微生物学
- 环境健康 环境健康
背景情况:
- 环境温度影响疾病病理,历史上的信仰将寒冷的天气与类风湿性关节炎 (RA) 联系起来.
- 慢性感冒暴露对RA的影响背后的分子机制在很大程度上仍未被探索,尽管有事证据.
研究的目的:
- 在受控环境中研究慢性寒冷暴露对原诱导关节炎 (CIA) 的影响.
- 阐明肠道微生物群和胆酸特征在冷引起的RA恶化中的作用.
主要方法:
- 与中央情报局的老鼠被暴露在慢性寒冷条件下.
- 分析了肠道微生物群组成,胆酸概况和炎症标志物.
- 干预措施包括抗生素治疗和便微生物群移植 (FMT).
- 通过口服补充 taurohyodeoxycholic 酸 (THDCA) 进行了测试.
主要成果:
- 慢性感冒暴露加剧了CIA,增加了胀,骨质侵蚀和细胞因子水平.
- 暴露于寒冷的老鼠表现出肠道失调,Lachnospiraceae和Ruminococcaceae的数量减少.
- 抗生素和FMT部分扭转了感冒引起的关节炎的严重程度.
- 暴露在寒冷中改变了胆酸概况,特别是降低了THDCA,这与TGR5-cAMP-PKA轴和NLRP3炎症酶激活相关.
- 补充THDCA缓解了感冒引起的RA恶化.
结论:
- 异常的肠道微生物群衍生的胆酸在与寒冷接触相关的RA中起着重要作用.
- 准肠道微生物群和THDCA补充剂为冷加重的RA提供了潜在的治疗策略.
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