暴露引起男性不孕症,由SD大鼠的丸和精子代谢功能障碍表明
Jing Li1, Bingru Nan2, Zehua Xu1
1State Key Laboratory of Infectious Disease Vaccine Development, Xiang An Biomedicine Laboratory & State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, School of Public Health, Xiamen University, Xiamen 361003, PR China.
The Science of the total environment
|September 9, 2023
概括
来自酸 (NaAsO2) 的暴露会通过损害精子质量和降低怀孕率来损害雄性大鼠的生育能力. 精子中的多可萨赫萨酸 (DHA) 水平可能表明不孕症风险.
科学领域:
- 环境毒理学环境毒理学
- 生殖生物学 生殖生物学
- 代谢学 代谢学 代谢学
背景情况:
- 污染是一个重要的环境问题.
- 暴露与男性生殖损害有关,但分子机制尚不清楚.
研究的目的:
- 为了研究将甲酸盐 (NaAsO2) 暴露与大鼠男性不孕症相关的分子事件.
- 评估NaAsO2对丸组织学,精子质量和生殖结果的影响.
主要方法:
- 成年雄性大鼠在饮用水中暴露在NaAsO2中八周.
- 通过H&E染色和传输电子显微镜评估丸损伤.
- 评估精子质量,女性怀孕率,并对丸和精子进行代谢学分析.
主要成果:
- 暴露于NaAsO2导致丸缩和亡.
- 精子活力下降,形增加.
- 精子代谢物被破坏,减少了多可萨赫萨酸 (DHA),与减少的怀孕率相关.
结论:
- 暴露于酸 (NaAsO2) 诱导通过精子损伤在老鼠中的男性不孕症.
- 减少男性生育能力会影响女性怀孕率,但胎儿生长不受影响.
- 多可萨赫萨酸 (DHA) 可能作为诱导的男性不孕症的生物标志物,并建议潜在的饮食干预措施.
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