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基于全基因组测序的编目,对猪场废弃物中抗生素耐药基因的样本进行分类

Jagana Niharika¹, Priyanka Thakur¹, Gyanendra Singh Sengar²

¹ICAR-National Research Centre on Pig, Guwahati 781131, Assam, India; All India Institute of Hygiene and Public Health, Government of India, Kolkata, West Bengal, India.

|September 9, 2023

概括

抗生素耐药性基因在印度养猪场废物中含量惊人高,对公众健康构成威胁. 这项研究强调,迫切需要制定畜牧业抗菌素耐药性 (AMR) 管理政策.

科学领域:

兽医微生物学兽医微生物学
基因组学就是基因组学.
公共卫生公共卫生

背景情况:

全球抗菌素耐药性 (AMR) 的上升主要是由于畜牧业的抗生素使用.
在动物群体中缺乏关于AMR的全面研究.

研究的目的:

来自印度西孟加拉邦的猪场废物样本中的细菌抗生素耐药性基因 (ARG) 的特征.
为印度畜牧业开发AMR管理策略提供信息.

主要方法:

全基因组测序 (WGS) 用于分析猪场废物中的ARG.
从包括屠宰场废物在内的养猪场废物中采集样本.

主要成果:

检测到高水平的Enterobacteriaceae表现出对常见抗生素 (beta-lactam,aminoglycoside,硫胺,四环素) 的耐药性.
确定了携带多抗药性肠杆菌菌种的等离子体,包括对最后手段药物如胆素和碳烯的耐药性.

结论:

西孟加拉邦的养猪场废物中含有大量抗生素耐药基因,导致AMR危机.
调查结果强调了印度猪业需要大规模查和强有力的抗菌耐药性管理政策的必要性.

关键词:

抗生素耐药性基因是抗生素耐药性的基因.猪猪猪猪猪猪猪猪猪猪猪猪猪猪猪猪猪猪猪猪猪猪这是一种等离子体.整个基因组的测序.

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