全球变暖及其对表皮屏障破坏,呼吸道和皮肤过敏疾病的影响
Zeynep Çelebi Sözener1, Elsa R Treffeisen2, Betül Özdel Öztürk3
1Division of Immunology and Allergic Diseases, Ankara Bilkent City Hospital, Ankara, Turkey.
The Journal of allergy and clinical immunology
|September 9, 2023
概括
全球变暖影响皮肤和呼吸道障碍,增加过敏性鼻炎,喘和皮炎. 极端温度和污染加剧了这些情况,影响了屏障完整性和炎症.
科学领域:
- 环境科学 环境科学
- 皮肤病学 皮肤病学
- 肺部病理学 肺部病理学
背景情况:
- 全球变暖对人类健康产生直接和间接影响.
- 呼吸道和皮肤屏障特别容易受到环境变化的影响.
- 最近的文献强调了过敏和炎症性皮肤疾病的发病率越来越高.
研究的目的:
- 审查全球变暖对呼吸道和皮肤屏障的影响.
- 探索这些影响的临床后果.
- 专注于过去三年内出版的文学作品.
主要方法:
- 科学文献的叙述性审查.
- 分析过去3年发表的研究.
- 综合了关于环境影响对屏障功能的研究结果.
主要成果:
- 极端的温度会破坏气道上皮屏障,导致炎症和过度反应.
- 热应激激活热冲击蛋白,恶化屏障功能障碍和炎症.
- 空气污染物和极端天气事件增加了亚托皮炎和喘的发病率和爆发.
结论:
- 全球变暖显著影响呼吸道和皮肤屏障健康.
- 过敏性鼻炎,喘和亚托皮性皮炎的频率和严重程度增加与气候变化有关.
- 需要进一步的研究来减轻这些健康后果.
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