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Updated: Jul 16, 2025

Mechanical Stimulation-induced Calcium Wave Propagation in Cell Monolayers: The Example of Bovine Corneal Endothelial Cells
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选择性抑制大麻素CB1受体引起的信号传递,由相互作用蛋白质GAP43进行

Irene B Maroto1, Estefanía Moreno2, Carlos Costas-Insua1

  • 1Department of Biochemistry and Molecular Biology, Instituto Universitario de Investigación Neuroquímica (IUIN), Complutense University, 28040, Madrid, Spain; Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas (CIBERNED), Instituto de Salud Carlos III, 28029, Madrid, Spain; Instituto Ramón y Cajal de Investigación Sanitaria (IRYCIS), 28034, Madrid, Spain.

Neuropharmacology
|September 9, 2023
PubMed
概括

增长相关蛋白43 (GAP43) 通过Gq/11合选择性抑制大麻素受体1 (CB1R) 信号传递,影响神经元外生长. 这种相互作用阻断了CB1R介导的ROCK激活,揭示了一个新的信号通路.

关键词:
大麻素CB(1) 受体受体细胞信号传输是如何进行的43kDa的与生长相关的蛋白质.含有Rho相关的蛋白质激酶的卷曲-卷曲.

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