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与参考标准相比,Aspergillus特定的IgG抗体用于诊断慢性肺阿斯伯吉洛症

Helmut J F Salzer¹, Maja Reimann², Carolin Oertel²

¹Division of Infectious Diseases and Tropical Medicine, Department of Internal Medicine 4 - Pneumology, Kepler University Hospital, Linz, Austria; Medical Faculty, Johannes Kepler University Linz, Linz, Austria; Ignaz-Semmelweis-Institute, Interuniversity Institute for Infection Research, Vienna, Austria.

Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases

|September 9, 2023

概括

Aspergillus特异性IgG抗体测试显示了诊断慢性肺阿斯伯吉洛症 (CPA) 的高灵敏度. 然而,由于潜在的假阳性结果,积极的结果需要与放射学发现进行确认.

科学领域:

医学真菌学医学真菌学
临床诊断临床诊断临床诊断
免疫学免疫学免疫学

背景情况:

慢性肺性阿斯伯吉洛症 (CPA) 诊断可能具有挑战性.
准确的诊断工具对于有效的患者管理至关重要.

研究的目的:

评估Aspergillus特异性IgG抗体对CPA的诊断性能.
将CPA患者的抗体标位与对照组进行比较.

主要方法:

研究了47名患有组织学证明的CPA的患者队列.
从303个病人和健康对照组收集了血清.
使用ImmunoCAP®测定法测量了阿斯伯吉路斯特异性IgG抗体标位,≥50 mgA/L被认为是阳性.

主要成果:

在ImmunoCAP® Aspergillus特异性IgG抗体测试中,CPA诊断的灵敏度为85.1%,特异性为83.6%.
与对照组相比,CPA患者的抗体标位明显高 (中位数为83.45 mgA/L).
在大约三分之一的健康对照中观察到假阳性结果.

结论:

特定于阿斯伯吉勒斯菌的IgG抗体测试是CPA的一个敏感的诊断标记.
积极的测试结果应与放射学发现结合解释,以避免由于假阳性导致的误诊.

关键词:

阿斯珀吉勒斯菌特有的IgG抗体.在美国,CPA是CPA.参考标准是一个参考标准.

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