针对肝细胞癌的天然多糖的近期进展:一篇综述
Dazhen Wang1, Zhengfeng Zhang1, Lu Zhao1
1Harbin Medical University Cancer Hospital, Harbin 150081, China.
International journal of biological macromolecules
|September 9, 2023
概括
天然多糖 (NP) 是治疗肝细胞癌 (HCC) 的安全有效替代品. 它们表现出抗HCC活性,可以减轻化疗副作用,提供新的治疗途径.
科学领域:
- 在瘤学瘤学.
- 自然产品化学 自然产品化学
- 药理学 药理学是指药理学的学科.
背景情况:
- 肝细胞癌 (HCC) 是一个重大的全球健康挑战.
- 目前用于HCC的化疗方法的疗效有限,副作用严重.
- 天然多糖 (NP) 正在成为潜在的安全和有效的治疗剂.
研究的目的:
- 综合审查天然多糖的抗HCC活性.
- 探索NP的抗癌作用背后的机制.
- 评估NP在缓解化疗引起的毒性方面的作用.
主要方法:
- 在体外研究评估抗增殖和细胞毒性作用.
- 在体内动物模型中评估治疗疗效和安全性.
- 对人类疗效的临床试验数据的分析.
- 机械学研究研究了亡,细胞循环,血管生成和免疫调节.
主要成果:
- 天然多糖体在体外,动物和临床研究中显示出显著的抗HCC活性.
- NP可以减少化疗相关的副作用,包括免疫毒性和骨髓抑制.
- 机制包括诱导亡,细胞循环停止,抗血管生成和免疫刺激.
- NP的物理化学特性,如单糖化合物组成和分子量,影响其抗癌作用.
结论:
- 自然的多糖体代表了肝细胞癌的有前途的治疗策略.
- NP提供了直接抗瘤活性和改善化疗副作用的双重好处.
- 对NP结构-活动关系的进一步研究可以优化其临床应用.
- NP显示了作为药物载体的潜力,可以增强化疗的输送.
相关概念视频
01:26Biosynthesis of Polysaccharides
37
Polysaccharides such as glycogen and starch are synthesized from nucleoside diphosphate sugars, primarily uridine diphosphate glucose (UDPG) and adenosine diphosphate glucose (ADPG). These activated glucose donors act as key intermediates in carbohydrate metabolism and biosynthesis. UDPG primarily involves glycogen synthesis in animals and many bacteria, while ADPG plays a fundamental role in starch synthesis in plants and certain bacteria.UDPG is formed when glucose-1-phosphate reacts with...
37
02:57Targeted Cancer Therapies
7.7K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
7.7K