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来自Anoectochilus roxburghii (Wall.) 的金赛诺化物林德尔. 林德尔. 林德尔. 林德尔. 林德尔. 林德尔. 林德尔. 林德尔. 林德尔.

Yu Xiao¹, Changsong Duan¹, Pushuang Gong¹

¹Engineering Research Center of Sichuan-Tibet Traditional Medicinal Plant, Chengdu University, Chengdu, 610106, China; College of Food and Biological Engineering, Chengdu University, Chengdu, 610106, China.

Journal of ethnopharmacology

|September 9, 2023

概括

昆化物是Anoectochilus roxburghii的主要活性成分,通过激活ERK/Nrf2通路并减少小鼠的氧化应激,可缓解衰老和记忆衰退.

科学领域:

药理学药理学是指药理学的学科.
神经科学是一个神经科学.
传统中国医药传统中国医药

背景情况:

阿诺克托奇勒斯罗克斯堡 (AR) 是一种有价值的传统中医药,用于治疗各种疾病.
它对衰老和与年龄相关的认知衰退的影响及其主要活性成分仍然未被探索.

研究的目的:

在体内研究AR (AEAR) 水性提取物对抗衰老和记忆障碍的保护作用.
确定AEAR的主要活性成分并阐明其作用机制.

主要方法:

使用D-银糖诱导衰老的小鼠模型和暴露于谷氨酸的HT22细胞.
使用莫里斯水迷宫,免疫组织化学和生化分析来评估效应.
研究AEAR和Kinsenoside (Kin) 的抗氧化作用和机制,在体外使用细胞活力测试,qRT-PCR,西部抹杀和分子对接.

主要成果:

在老年小鼠中,AEAR治疗改善了生理特征和认知功能,与维生素C相当或高于维生素C.
AEAR和Kin降低了氧化应激标志物 (SOD,GSH-PX,GSH/GSSG比,MDA) 并促进了大脑中的Nrf2核转移.
基因在体外表现出优异的抗氧化作用,并激活了ERK/Nrf2通路,与AEAR一致.

结论:

昆塞诺化物被确定为AR的主要活性成分,负责抗衰老作用.
基因通过激活ERK/Nrf2信号通路来缓解氧化压力和与年龄相关的认知障碍.

关键词:

衰老的衰老衰老的衰老安诺科奇勒斯·罗克斯堡希 (瓦尔兰) (英语:Anoectochilus roxburghii) 是一种葡萄牙的植物. 林德尔. 林德尔. 林德尔. 林德尔. 林德尔. 林德尔. 林德尔. 林德尔. 林德尔.通过ERK/Nrf2路径.这是一种昆塞诺化物.学习和记忆障碍学习和记忆障碍氧化应激是一种氧化应激.

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