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相关概念视频

Teratogenicity01:07

Teratogenicity

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The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...
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Physiological Barriers01:25

Physiological Barriers

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Physiological barriers are semi-permeable cellular structures restricting drug diffusion into intracellular compartments and tissues. There are six types of physiological barriers: blood endothelial, cell membrane, blood-brain, blood-cerebrospinal fluid (CSF), blood-placenta, and blood-testis barriers.
The blood endothelial barrier is the most porous of these. It allows all small ionized, un-ionized, and lipophilic molecules to pass through the endothelial lining into the interstitial space...
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相关实验视频

Updated: Jul 16, 2025

Comprehensive Evaluation of the Effectiveness and Safety of Placenta-Targeted Drug Delivery Using Three Complementary Methods
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Comprehensive Evaluation of the Effectiveness and Safety of Placenta-Targeted Drug Delivery Using Three Complementary Methods

Published on: September 10, 2018

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在母胎界面上的纳米粒子.

S Adams1, P A Stapleton2

  • 1Department of Pharmacology and Toxicology, USA.

Molecular and cellular endocrinology
|September 9, 2023
PubMed
概括
此摘要是机器生成的。

环境纳米颗粒 (NP) 在怀孕期间存在风险. 本综述研究了NP特性如何影响它们穿过胎盘的转移以及胎儿潜在的内分泌干扰.

关键词:
内分泌系统内分泌系统内分泌系统母胎界面 母胎界面纳米颗粒是如何形成的物理化学特性 物理化学特性胎盘 胎盘 胎盘 胎盘吸收/转移的位置.

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Isolation of Leukocytes from the Human Maternal-fetal Interface
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Isolation of Leukocytes from the Human Maternal-fetal Interface

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相关实验视频

Last Updated: Jul 16, 2025

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科学领域:

  • 环境科学 环境科学
  • 毒理学 毒理学 毒理学
  • 生殖生物学 生殖生物学

背景情况:

  • 纳米粒子 (NP) 是越来越普遍的环境污染物.
  • 怀孕是一个关键的发育窗口,对环境暴露的敏感性增加.
  • 胎盘对于母胎交换至关重要,是NP积累和影响的潜在地点.

研究的目的:

  • 审查当前关于纳米粒子转位和母胎界面的细胞吸收的文献.
  • 确定影响胎盘中纳米粒子行为的物理化学因素.
  • 评估纳米颗粒对胎盘内分泌功能的影响.

主要方法:

  • 对研究纳米粒子 - 胎盘相互作用的文献综述.
  • 对NP物理化学性质 (大小,形状,组成,表面化学) 的研究分析.
  • 从人类和动物模型中对妊娠期NP暴露的证据的检查.

主要成果:

  • 纳米粒子的物理化学特性显著影响它们在胎盘上的转移.
  • 有证据表明NP可以穿过胎盘屏障,导致局部效应.
  • 孕期NP暴露与胎盘内分泌干扰有关.

结论:

  • 了解NP属性是预测胎盘转移和胎儿暴露的关键.
  • 需要进一步的研究来阐明NP吸收和胎盘内分泌干扰的精确机制.
  • 缓解环境NP暴露对于保护胎儿发育至关重要.