循环中的胆水平与肺高血压患者的预后有关:一项队列研究
Yicheng Yang1, Beilan Yang1, Bingyang Liu1
1Center of Pulmonary Vascular Disease, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Disease, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, 100037, China.
循环中胆水平升高与肺高血压 (PH) 患者的病情恶化有关. 这一发现表明,胆可能作为疾病严重程度和PH预后的潜在生物标志物,特别是肺动脉高血压.
科学领域:
- 心血管医学 心血管医学
- 代谢学 代谢学 代谢学
- 肺高血压研究 肺高血压研究
背景情况:
- 越来越多的证据将代谢物与心血管疾病联系起来.
- 之前的研究已经确定了胆代谢物三甲基胺氧化物,作为肺高血压 (PH) 的预后指标.
- 胆的作用,一个三甲基胺氧化物前体,在PH预后仍然未经调查.
研究的目的:
- 调查血液中的胆水平与诊断为PH的患者的预后之间的关联.
- 为了确定胆水平是否与PH患者的疾病严重程度相关.
主要方法:
- 招募了272名PH (平均肺动脉压≥25 mmHg) 的住院患者.
- 分析了禁食血液样本的胆水平和其他临床变量.
- 主要终点包括死亡,药物升级,心力衰竭再住院和PH恶化,随访持续时间记录.
主要成果:
- 循环中较高的胆水平与更差的世界卫生组织功能类相关,高的N终端亲B型性尿素,以及心脏输出指数的降低.
- 经过调整后的分析显示,高胆水平与PH患者的预后不佳显著相关 (HR=1.934,P=0.039).
- 亚组分析表明胆水平预测了肺动脉高血压的预后,但不是慢性血栓栓塞性肺高血压.
结论:
- 循环中的胆水平与PH患者的疾病严重程度增加和不良预后有关.
- 胆可以作为PH的潜在生物标志物,特别是在肺动脉高血压中.
- 对胆作用的进一步研究可以为PH的治疗策略提供信息.
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