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相关概念视频

Teeth01:15

Teeth

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The formation of teeth, also known as odontogenesis, is a complex process that begins in utero, around the sixth week of embryonic development. There are three stages to this process: the bud stage, the cap stage, and the bell stage.
In the bud stage, the tooth germ (an aggregation of cells) starts to form in the developing jawbone. During the cap stage, the tooth germ differentiates into enamel organ, dental papilla, and dental sac, which will later develop into the tooth's enamel, dentin...
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Study Designs in Epidemiology01:20

Study Designs in Epidemiology

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Epidemiological study designs are fundamental tools for investigating the distribution, determinants, and control of health conditions in populations. They help researchers understand the relationships between exposures and outcomes, and they broadly fall into two categories: "observational" and "experimental" studies.
Observational studies are those where the researcher does not intervene but rather observes natural variations. They include cross-sectional, cohort, and...
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Correlation means that there is a relationship between two or more variables (such as ice cream consumption and crime), but this relationship does not necessarily imply cause and effect. When two variables are correlated, it simply means that as one variable changes, so does the other. We can measure correlation by calculating a statistic known as a correlation coefficient. A correlation coefficient is a number from -1 to +1 that indicates the strength and direction of the relationship between...
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While variables are sometimes correlated because one does cause the other, it could also be that some other factor, a confounding variable, is actually causing the systematic movement in our variables of interest. For instance, as sales in ice cream increase, so does the overall rate of crime. Is it possible that indulging in your favorite flavor of ice cream could send you on a crime spree? Or, after committing crime do you think you might decide to treat yourself to a cone?
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Robust Ligature-Induced Model of Murine Periodontitis for the Evaluation of Oral Neutrophils
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咖啡消费和牙周炎:孟德尔随机化研究

Wan-Zhe Liao1,2, Zhi-Yi Zhou1,3, Zi-Kai Lin

  • 1Department of Clinical Laboratory Medicine, Guangdong Provincial Key Laboratory of Major Obstetric Diseases, Guangdong Provincial Clinical Research Center for Obstetrics and Gynecology, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510150, China.

Genes & nutrition
|September 9, 2023
PubMed
概括

连续增加的咖啡消费与牙周炎的风险更高有关. 二元咖啡消费与牙周炎风险没有显著的因果关系. 需要进一步的研究才能得出最终的结论.

关键词:
双向孟德尔随机化 双向孟德尔随机化咖啡的消费 咖啡的消费牙周健康 牙周健康牙周病是指牙周病的发生.

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科学领域:

  • 口腔卫生流行病学 口腔卫生流行病学
  • 营养流行病学 营养流行病学
  • 遗传流行病学遗传流行病学

背景情况:

  • 咖啡是全球普遍存在的饮料,在美国的消费量正在增加.
  • 牙周炎,以牙周组织破坏为特征,与全身疾病有关.
  • 咖啡摄入量与牙周炎风险之间的因果关系尚不清楚.

研究的目的:

  • 调查咖啡消费与牙周炎的潜在因果关系.
  • 为了区分连续和二进制咖啡消费模式的影响.

主要方法:

  • 利用孟德尔的随机化与来自英国生物银行,GLIDE和GWAS的遗传仪器进行元分析.
  • 作为因果推理的主要方法,使用逆方差加权 (IVW).
  • 进行散射图和稳定性测试以进行可靠的分析.

主要成果:

  • 确定了持续咖啡消费对牙周炎风险的统计学上显著的因果作用.
  • 咖啡消费的每一个标准偏差增加与牙周炎风险增加1.04%相关 (OR:1.0104).
  • 二元咖啡消费和反向因果关系分析没有产生显著的因果关系.

结论:

  • 持续的咖啡消费表明与牙周炎风险增加的因果关系,尽管影响规模很小.
  • 没有强有力的证据支持二元咖啡消费对牙周炎的因果关系.
  • 该研究没有发现有意义的反向因果关系证据.