相关实验视频
Updated: Jul 16, 2025

09:17
Using Retinal Imaging to Study Dementia
Published on: November 6, 2017
21.7K
各个年龄段的心血管疾病和痴呆症之间的关联:老年人群的基于人口的队列研究
Laurie-Anne Boivin-Proulx1, Judith Brouillette1,2, Marc Dorais3
1Department of Cardiology, Faculty of Medicine, University of Ottawa Heart Institute, Ottawa, ON, Canada.
Scientific reports
|September 9, 2023
概括
糖尿病和中风等心血管风险因素增加痴呆风险,但这种关联在老年人中减弱. 预防这些疾病是减轻不同年龄组痴呆风险的关键.
科学领域:
- 神经学 神经学
- 心脏病学 心脏病学
- 公共卫生 公共卫生
背景情况:
- 心血管 (CV) 风险因素/疾病和痴呆症之间的确立联系.
- 关于年龄作为这种关联的调节者,存在相互矛盾的证据.
- 需要澄清针对性干预的特定年龄的关联.
研究的目的:
- 调查不同年龄组内心血管风险因素/疾病和痴呆风险之间的关联.
- 确定年龄是否影响心血管健康和认知衰退之间的联系的强度.
- 为预防痴呆症提供临床和研究策略的信息.
主要方法:
- 使用北克医疗保健数据库 (1998-2010) 进行的回顾性队列研究.
- 包括320,630名没有痴呆症的成年患者.
- 评估与高血压,糖尿病,脂质失调,中风,心肌梗塞 (MI),慢性心力衰竭 (HF) 和心房 (AF) 相关的痴呆风险,使用发生率比率和跨年龄层的Cox回归.
主要成果:
- 痴呆的发病率随着年龄的增长而增加 (每1000人年4.1到93.5).
- 糖尿病,中风,HF和AF与痴呆症风险增加显著相关 (HRs1.08-3.54).
- 糖尿病,中风和HF与痴呆风险的关联强度在晚年减少.
结论:
- 预防糖尿病,中风,心力衰竭和心房动对于减轻痴呆风险至关重要.
- 痴呆的潜在病理生理学可能在年轻人和老年人群之间有所不同.
- 心血管风险因素似乎对晚年痴呆风险的影响较小.
相关概念视频
Dementia
139
Dementia is a collective term for cognitive disorders primarily affecting memory, thinking, and reasoning. It is not a specific disease but a syndrome, with Alzheimer's disease being the most common cause, accounting for approximately 60-80% of cases. Other types include vascular dementia, Lewy body dementia, and frontotemporal dementia. Dementia affects millions worldwide, particularly older adults, though it is not a normal part of aging.
The progression of dementia is generally gradual....
The progression of dementia is generally gradual....
139
Coronary Artery Disease I: Introduction
20
Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
20
Psychoneuroimmunology: Cardiovascular Disease
49
Psychoneuroimmunology (PNI) is a multidisciplinary field that examines how psychological factors, particularly stress, interact with the immune system and impact physical health. Research in PNI has shown that chronic or traumatic stress can disrupt both the hypothalamic-pituitary-adrenal axis and the sympathetic nervous system. These disruptions contribute to serious health conditions, including cardiovascular diseases.
A key area of focus in PNI is the relationship between stress and coronary...
A key area of focus in PNI is the relationship between stress and coronary...
49
Assessment of the Cardiovascular System I: Subjective Data
366
A thorough health history and physical assessment are essential for identifying cardiovascular disease (CVD) symptoms and distinguishing them from other health issues.
Initial Enquiry
Ask the patient about their primary concern and thoroughly explore all reported symptoms.
Medical History
Investigate past illnesses affecting the cardiovascular system, such as angina, anemia, rheumatic fever, congenital heart disease, stroke, thrombophlebitis, dysrhythmias, varicosities
Inquire about symptoms...
Initial Enquiry
Ask the patient about their primary concern and thoroughly explore all reported symptoms.
Medical History
Investigate past illnesses affecting the cardiovascular system, such as angina, anemia, rheumatic fever, congenital heart disease, stroke, thrombophlebitis, dysrhythmias, varicosities
Inquire about symptoms...
366
Alzheimer's Disease: Overview
517
Alzheimer's Disease (AD) is a continually advancing neurodegenerative disorder, distinguished by escalating memory loss, cognitive dysfunction, and dementia. The disease unfolds in three stages: preclinical, mild cognitive impairment (MCI), and dementia. Its onset is insidious, and the progression gradual, with the cause not well explained by other disorders.
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
517
Coronary Artery Disease III: Clinical Manifestations
13
Coronary Artery Disease (CAD) is a primary health risk worldwide, leading to significant morbidity and mortality. The condition arises from the buildup of atherosclerotic plaques within the coronary arteries, resulting in diminished blood supply to the heart muscle.The clinical manifestations of CAD vary widely, from asymptomatic stages to severe, life-threatening conditions. Understanding these manifestations is crucial for early diagnosis and effective management.Angina Pectoris: The Warning...
13

