麦可以通过重建肠道微生物组和循环代谢组来预防高脂肪饮食诱导的肌肉功能障碍,全身炎症和氧化应激
Rui Dong1, Kejie Peng1, Lin Shi1
1College of Food Engineering and Nutritional Science, Shaanxi Normal University, Xi'an, Shaanxi 710119, China.
Food research international (Ottawa, Ont.)
|September 10, 2023
概括
麦的消费改善了高脂肪饮食 (HFD) 的小鼠的骨肌功能. 它减轻炎症和肠道失调,证明其促进肌肉的特性.
科学领域:
- 营养科学 营养科学
- 骨肌肉生理学 骨肌肉生理学
- 肠道微生物组研究研究
背景情况:
- 西式高脂肪饮食可能会损害骨肌肉功能.
- 麦含有丰富的食纤维,因其健康益处而闻名.
研究的目的:
- 在小鼠中研究麦对由高脂肪饮食 (HFD) 诱导的骨肌肉功能障碍的影响.
- 阐明麦对肌肉健康的保护作用的潜在机制.
主要方法:
- 给小鼠食高脂肪饮食 (HFD),有或没有麦补充.
- 通过抓地力和跑步机运行测试来评估骨肌功能.
- 分析了基因表达,炎症性细胞因子,氧化应激标志物,肠道微生物组成和代谢学.
主要成果:
- 麦改善了HFD引起的骨肌肉异常,改善了握力和耐力.
- 麦抑制了炎症性细胞因子,增强了抗氧化酶 (超氧化脱酶,谷氨) 和调节了与肌肉相关的基因表达.
- 麦对肠道微生物群产生了积极的影响,增加了短链脂肪酸 (SCFA) 生产者和SCFA,同时减少了与炎症相关的代谢物.
结论:
- 麦的消费可以防止与高脂肪饮食相关的骨肌肉功能障碍.
- 益处通过缓解炎症,改善肠道失调和优化全身新陈代谢来实现.
- 麦通过涉及肠道微生物群和代谢途径的新机制表现出促进肌肉的特性.
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