克服与口服输送不同尺寸的光核心-晶纳米颗粒相关的障碍
Jacob A Erstling1,2, Nirmalya Bag3, Thomas C Gardinier1
1Department of Materials Science and Engineering, Cornell University, Ithaca, NY, 14853, USA.
Advanced materials (Deerfield Beach, Fla.)
|September 10, 2023
概括
光化纳米颗粒显示出口服药物输送的前景. 超微小的纳米粒子 (小于10纳米) 能够有效地穿越肠道屏障,这表明临床翻译的潜力.
科学领域:
- 纳米技术纳米技术
- 材料科学 材料科学 材料科学
- 生物医学工程 生物医学工程
背景情况:
- 口服药物输送是非常理想的,但面临着重要的生物障碍.
- 聚乙烯糖醇涂层 (PEGylated) 纳米粒子正在研究药物管理.
- 了解纳米粒子与生物障碍物的相互作用对于有效的口服输送至关重要.
研究的目的:
- 为了研究光PEGylated纳米颗粒 (5-50nm) 与肠,上皮和胃酸的相互作用.
- 评估超小纳米颗粒 (Cornell prime点,C'点) 在口服药物输送中的潜力.
主要方法:
- 影像光相关谱与近乎总的内部反射光显微镜.
- 使用Caco-2细胞单层模仿肠道表皮的研究.
- 在人造胃汁中进行了体外稳定性测试,并在小鼠体内进行了体内口腔测试.
主要成果:
- 在20nm以上,粘液中的纳米粒子扩散受到阻碍.
- 超微小的纳米颗粒 (<10 nm) 显示出通过肠道紧密结的增强的被动通道.
- 较大的纳米粒子 (>20 nm) 通过细胞被积极运输.
- C'dots在胃部条件下表现出稳定性,并且在体内成功通过清除.
结论:
- 超微小的二氧化纳米粒子 (C'点) 显示出口服药物输送的潜力,因为它们有能力克服生物障碍.
- 这些发现支持C'dots.的临床转化途径.
- 进一步研究作为食品添加剂及其对健康的影响是有必要的.
相关概念视频
01:23Factors Affecting Dissolution: Particle Size and Effective Surface Area
Dissolution kinetics, an essential aspect of oral drug delivery, is significantly influenced by the drug's particle size. According to the Noyes-Whitney dissolution model, the dissolution rate correlates directly with the drug's surface area. The larger the surface area, the higher the drug's solubility in water, leading to a faster drug dissolution rate. Reducing particle size increases the effective surface area, enhancing the dissolution process. Micronization and nanosizing are employed to...
01:23Oral Drug Delivery Systems: Introduction
Oral drug delivery is the most common route of administration due to its convenience, cost-effectiveness, and high patient compliance. It enables precise formulation to ensure proper drug dosage and bioavailability. The development of oral dosage forms considers drug properties such as solubility, stability, and absorption to optimize therapeutic efficacy.Tablets, capsules, liquids, and chewable formulations enhance drug stability, mask undesirable tastes, and improve patient experience.