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阿尔多斯特 - 列宁比率与骨参数之间的关联来自周围定量计算机断层扫描和男性冲击微印记

Kara L Holloway-Kew¹, Kara B Anderson², Pamela Rufus-Membere²

¹IMPACT - the Institute for Mental and Physical Health and Clinical Translation, School of Medicine, Deakin University, Geelong, Australia. k.holloway@deakin.edu.au.

Calcified tissue international

|September 10, 2023

概括

高的阿尔多-因比 (ARR) 可能会对男性的骨健康产生负面影响. 可能的原发性阿尔多斯特隆症与骨面积的减少有关,但与骨材料强度无关.

科学领域:

内分泌学在内分泌学.
骨生物学骨生物学骨生物学
代谢性骨病代谢性骨病

背景情况:

氨酸- ангиотензин- алдостерон系统 (RAAS) 在骨细胞功能中起作用.
阿尔多斯特-因比 (ARR) 是原发性阿尔多斯特主义的一个关键指标.
关于ARR和骨矿物质密度的现有研究显示了相互矛盾的结果.

研究的目的:

调查ARR与通过外围定量计算断层扫描 (pQCT) 和冲击微印记 (IMI) 测量的骨参数之间的关联.
探索可能或可能的原发性阿尔多斯特和男性骨健康之间的关系.

主要方法:

对吉隆骨质疏松症研究中的431名男性参与者的数据进行分析.
定义"可能"的原发性阿尔多斯特隆症 (ARR ≥70 pmol/mIU) 和"可能"的原发性阿尔多斯特隆症.
使用pQCT和骨材料强度指数 (BMSi) 通过IMI评估骨参数.

主要成果:

在ARR或阿尔多素水平和pQCT衍生骨参数之间没有发现显著的关联.
患有"可能"原发性阿尔多斯特隆症 (n=16) 的男性在半径66%部位 (-12.5%) 的调整总骨面积显著减少.
没有观察到"可能"的原发性阿尔多斯特隆症或与BMSi的关联.

结论:

临床上显著的ARR升高可能会对男性的骨区域产生负面影响.
需要进一步的研究来阐明将RAAS活动与骨健康结果联系在一起的特定机制.

关键词:

阿尔多素与仁素的比率骨材强度指数骨材强度指数冲击微缩水的产生.它们的雄性是雄性,雄性是雄性.周边定量计算断层扫描技术 (PCT)主要的阿尔多斯特主义.

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