男性焦虑和抑郁对试管婴儿结果的影响
Zachary Walker1,2, John Ernandez2,3, Andrea Lanes1,2
1Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology and Infertility, Brigham & Women's Hospital, Boston, MA, USA.
Human reproduction (Oxford, England)
|September 10, 2023
概括
经过试管婴儿的焦虑男性的精子数量较低,但活产率相似. 在生育治疗期间,心理健康支持对双方都至关重要,因为焦虑和抑郁不会对试管婴儿成功率产生负面影响.
科学领域:
- 生殖医学 生殖医学
- 在不孕症中的心理健康
- 精子参数和试管婴儿结果
背景情况:
- 男性的焦虑和抑郁越来越被认为是影响在体外受精 (IVF) 的夫妇的潜在因素.
- 以前的研究表明,男性焦虑和精子质量下降之间存在联系,但与试管婴儿结果的直接关联仍然不清楚.
研究的目的:
- 研究男性焦虑和抑郁对体外受精 (IVF) 结果的影响.
- 确定男性伴侣的心理健康状况是否会影响试管婴儿期间的活产率 (LBR) 和精液参数.
主要方法:
- 一项回顾性队列研究,涉及222名接受试管婴儿/ICSI的男性伴侣.
- 参与者填写了医院焦虑和抑郁量表 (HADS) 调查问卷.
- 评估的结果包括LBR,精液参数 (fTMSC),勃起功能障碍和低性欲的发生率.
主要成果:
- 与没有焦虑的男性相比,患有焦虑症 (HADS-A ≥8) 的男性的最终总运动精子数 (fTMSC) 较低,但活产率 (LBR) 类似.
- 在患有抑郁症和没有抑郁症的男性之间没有观察到LBR或FTMSC的显著差异 (HADS-D ≥8).
- 在报告焦虑或抑郁症的男性中,抗抑郁药的使用率更高,但LBRs仍然不受影响.
结论:
- 男性焦虑与精子运动率降低有关,但似乎不会影响试管婴儿活产率.
- 对接受试管婴儿的男性伴侣进行心理健康查和治疗非常重要,因为焦虑和抑郁症不会阻止成功的受孕.
- 研究结果支持在生育治疗期间继续为男性提供心理健康治疗,而不必担心对试管婴儿结果的不良影响.
相关概念视频
Infertility in Males
295
Male infertility affects millions of couples worldwide, arising from various factors that impact different stages of the reproductive process. An endocrine imbalance resulting from conditions like hypogonadism, Klinefelter syndrome, or pituitary disorders can disrupt hormone levels and reduce sperm production. Testicular defects, such as tumors, cryptorchidism, atrophic testes, abnormal sperm morphology, and low sperm count or motility, may arise due to genetic factors, structural...
295
Infertility in Females
348
Female infertility is defined as the inability to conceive after a year of regular, unprotected intercourse and affects about 10–15% of couples worldwide. The primary cause of female infertility is ovulatory disorders, which hinder the release of eggs. These disorders can be classified as hypothalamic amenorrhea, polycystic ovarian syndrome (PCOS), premature ovarian failure, and hyperprolactinemic anovulation disorders.
Endometriosis, a condition characterized by abnormal growth of...
Endometriosis, a condition characterized by abnormal growth of...
348
In Vitro Fertilization
326
In vitro fertilization (IVF) is a form of assisted reproductive technology where an egg is fertilized with sperm in a controlled laboratory environment before transferring the resulting embryo into the uterus. This process is designed to help individuals and couples experiencing difficulties conceiving.
The IVF process begins with ovarian stimulation, during which reproductive endocrinologists prescribe hormonal medications to stimulate the ovaries to produce multiple eggs instead of the single...
The IVF process begins with ovarian stimulation, during which reproductive endocrinologists prescribe hormonal medications to stimulate the ovaries to produce multiple eggs instead of the single...
326
Disorders of the Male Reproductive System
453
Men's health issues are increasingly recognized as significant, with several conditions posing common threats. Among these, testicular cancer is especially prevalent in younger men, particularly those aged 20 to 35 years. The disease often manifests as a painless mass in the testicles, sometimes accompanied by a sensation of heaviness or a dull ache.
Prostate disorders are another major concern. These conditions can impair urinary flow due to the prostate's location around the urethra....
Prostate disorders are another major concern. These conditions can impair urinary flow due to the prostate's location around the urethra....
453
Spermatogenesis
102.6K
Spermatogenesis is the process by which haploid sperm cells are produced in the male testes. It starts with stem cells located close to the outer rim of seminiferous tubules. These spermatogonial stem cells divide asymmetrically to give rise to additional stem cells (meaning that these structures “self-renew”), as well as sperm progenitors, called spermatocytes. Importantly, this method of asymmetric mitotic division maintains a population of spermatogonial stem cells in the male...
102.6K
Stress and Mental Health
179
Chronic stress profoundly affects mental health, significantly influencing mood, behavior, and overall quality of life. Research closely links chronic stress with mental health conditions such as depression, anxiety, and substance use disorders. Ongoing exposure to stress can lead to physiological and psychological changes, initiating a cycle of emotional distress and maladaptive coping mechanisms.
Individuals with depression often experience challenges in both their personal and professional...
Individuals with depression often experience challenges in both their personal and professional...
179


