在精神分裂症中听觉奇怪的低活化
Soichiro Nakahara1, Alie G Male2, Jessica A Turner3
1Clinical Translational Neuroscience Laboratory, Department of Psychiatry and Human Behavior, University of California Irvine, Irvine, CA, 92617, United States; Discovery Accelerator Venture Unit Direct Reprogramming, Astellas Pharma Inc, 21, Miyukigaoka, Tsukuba, Ibaraki 305-8585, Japan.
Psychiatry research. Neuroimaging
|September 10, 2023
概括
精神分裂症患者在听觉任务中表现出减少的大脑活化. 这项研究将这种低活化与认知缺陷和特定遗传因素联系起来,为这种疾病提供了新的见解.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 遗传学 是一个遗传学.
背景情况:
- 精神分裂症 (SZ) 患者在听觉奇怪任务中表现出改变的大脑活动,但与认知和遗传学的联系尚不清楚.
- 功能磁共振成像 (fMRI) 研究显示SZ中异常的神经激活,需要进一步调查认知和遗传相关性.
研究的目的:
- 为了比较精神分裂症 (SZ) 和健康志愿者 (HVs) 在听觉奇怪任务期间的大脑激活模式.
- 调查大脑活动,认知表现,精神分裂多原风险得分 (PRS) 和SZ的遗传位置之间的关联.
主要方法:
- 分析了两个横截面的多中心数据集,比较了SZ (n=228) 和HVs (n=245).
- fMRI用于评估听觉奇怪任务期间的大脑激活.
- 认知表现,PRS和遗传变异 (SNPs) 被检查与大脑活动相关.
主要成果:
- 与HV相比,SZ在包括左额头极,右额头轨道皮质,前骨和海马体在内的区域始终显示出低活性.
- 在SZ中,降低的前性活动与认知表现有积极的相关性.
- 精神分裂症PRS与右上边皮质活动负相关,与特定的SNP和RPL36基因相关,与该区域的活动有关.
结论:
- 这项研究复制了在听觉奇怪任务期间SZ中低激活的发现.
- 他们发现了区域大脑活动,认知功能和精神分裂症的遗传因素之间的新关联.
- 研究结果强调需要继续共享数据和合作研究,以进一步阐明精神分裂症的神经生物学基础.
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