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相关概念视频

Positive Symptoms of Schizophrenia: Hallucinations and Delusions01:30

Positive Symptoms of Schizophrenia: Hallucinations and Delusions

148
Schizophrenia is a complex mental health disorder that can manifest with various positive symptoms, including thought, movement, and behavior disorders. These symptoms significantly disrupt cognitive and motor functions, leading to profound effects on an individual's ability to engage with the world.
Thought Disorders
Disorganized and unusual thought processes mark thought disorders in schizophrenia. One key feature is disorganized speech, where an individual's conversation includes...
148
Negative and Cognitive Symptoms of Schizophrenia01:30

Negative and Cognitive Symptoms of Schizophrenia

65
Negative symptoms of schizophrenia indicate a reduction or absence of typical behaviors and emotional responses found in healthy individuals, while positive symptoms reflect an excess or distortion of normal functioning.
Negative Symptoms
Negative symptoms of schizophrenia manifest as deficits in normal emotional and behavioral functioning, profoundly impacting daily life. Individuals with schizophrenia often display a flat affect, characterized by a near-total absence of emotional expression,...
65
Schizophrenia01:17

Schizophrenia

109
Schizophrenia, a term introduced by Swiss psychiatrist Eugen Bleuler in 1911, describes a severe psychological disorder marked by profound disruptions in attention, thought processes, language, emotion, and interpersonal relationships. The core feature of schizophrenia is psychosis — a state characterized by a fundamental detachment from reality. This disconnection manifests through distorted logic, impaired perception, and atypical behavior, severely affecting the lives of those...
109
Positive Symptoms Schizophrenia: Hallucinations and Delusions01:26

Positive Symptoms Schizophrenia: Hallucinations and Delusions

77
Schizophrenia is a complex psychiatric disorder characterized by a range of symptoms that significantly impact cognition, behavior, and emotional regulation. Among these, the positive symptoms stand out as they involve the addition or exaggeration of normal mental functions, deviating markedly from typical behavior and perception. Hallucinations and delusions are prominent positive symptoms, each profoundly affecting the individual's experience of reality.
Hallucinations
Hallucinations in...
77
Biological Causes of Schizophrenia01:29

Biological Causes of Schizophrenia

77
Schizophrenia, a severe psychiatric disorder, arises from a complex interplay of biological factors, including genetic predisposition, structural brain abnormalities, neurotransmitter dysregulation, and developmental irregularities. These factors collectively contribute to the onset and progression of the disorder, which typically manifests in late adolescence or early adulthood.
Genetic Factors in Schizophrenia
The genetic basis of schizophrenia is strongly supported by family and twin...
77
Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders01:27

Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders

737
Schizophrenia is a neurodevelopmental disorder whose origins are rooted in complex genetic components. Despite our burgeoning understanding, the pathophysiology of this disorder remains incompletely deciphered.
Researchers have identified genetic factors that increase susceptibility to schizophrenia, underscoring the intricate interplay between genetics and environment in disease development. At the core of schizophrenia's pathophysiology is excessive dopaminergic neurotransmission within...
737

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相关实验视频

Updated: Jul 16, 2025

Measurement of Fronto-limbic Activity Using an Emotional Oddball Task in Children with Familial High Risk for Schizophrenia
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在精神分裂症中听觉奇怪的低活化.

Soichiro Nakahara1, Alie G Male2, Jessica A Turner3

  • 1Clinical Translational Neuroscience Laboratory, Department of Psychiatry and Human Behavior, University of California Irvine, Irvine, CA, 92617, United States; Discovery Accelerator Venture Unit Direct Reprogramming, Astellas Pharma Inc, 21, Miyukigaoka, Tsukuba, Ibaraki 305-8585, Japan.

Psychiatry research. Neuroimaging
|September 10, 2023
PubMed
概括

精神分裂症患者在听觉任务中表现出减少的大脑活化. 这项研究将这种低活化与认知缺陷和特定遗传因素联系起来,为这种疾病提供了新的见解.

关键词:
认知 认知是一种认知.功能性核磁共振成像 (MRI) 是一种功能性核磁共振成像.全基因组关联分析分析.图像成像技术可以提供图像.多基因风险评分多基因风险评分.复制复制复制复制复制复制复制

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科学领域:

  • 神经科学是一个神经科学.
  • 精神病学是一个精神病学.
  • 遗传学 是一个遗传学.

背景情况:

  • 精神分裂症 (SZ) 患者在听觉奇怪任务中表现出改变的大脑活动,但与认知和遗传学的联系尚不清楚.
  • 功能磁共振成像 (fMRI) 研究显示SZ中异常的神经激活,需要进一步调查认知和遗传相关性.

研究的目的:

  • 为了比较精神分裂症 (SZ) 和健康志愿者 (HVs) 在听觉奇怪任务期间的大脑激活模式.
  • 调查大脑活动,认知表现,精神分裂多原风险得分 (PRS) 和SZ的遗传位置之间的关联.

主要方法:

  • 分析了两个横截面的多中心数据集,比较了SZ (n=228) 和HVs (n=245).
  • fMRI用于评估听觉奇怪任务期间的大脑激活.
  • 认知表现,PRS和遗传变异 (SNPs) 被检查与大脑活动相关.

主要成果:

  • 与HV相比,SZ在包括左额头极,右额头轨道皮质,前骨和海马体在内的区域始终显示出低活性.
  • 在SZ中,降低的前性活动与认知表现有积极的相关性.
  • 精神分裂症PRS与右上边皮质活动负相关,与特定的SNP和RPL36基因相关,与该区域的活动有关.

结论:

  • 这项研究复制了在听觉奇怪任务期间SZ中低激活的发现.
  • 他们发现了区域大脑活动,认知功能和精神分裂症的遗传因素之间的新关联.
  • 研究结果强调需要继续共享数据和合作研究,以进一步阐明精神分裂症的神经生物学基础.