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Updated: Jul 16, 2025

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氧化应激的细胞外微环境驱动纤维细胞激活和纤维化

Li Li1, Meizhi Lu1, Yiling Peng1

  • 1State Key Laboratory of Organ Failure Research, National Clinical Research Center of Kidney Disease, Guangdong Provincial Institute of Nephrology, and Division of Nephrology, Nanfang Hospital, Southern Medical University, Guangzhou, China.

Redox biology
|September 10, 2023
PubMed
概括

氨酸过氧化酶-3 (GPX3) 在损伤中的损失会产生氧化应激,通过激活纤维细胞来驱动纤维化. 向NADPH氧化酶-4 (NOX4) 可以减少这种激活并缓解纤维化.

关键词:
细胞外微观环境 细胞外微环境纤维细胞激活的激活在GPX3中使用GPX3.脏纤维化 脏纤维化氧化应激是一种氧化应激.

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