COVID-19 pfizer BioNTech mRNA疫苗和发作的发生频率
Alon Doron1, Tamar Eviatar-Ribak2, Aya Vituri3
1Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
BNT162b2 mRNA疫苗 (Pfizer-BioNTech) 在患者中没有增加发作频率. 大规模的COVID-19疫苗接种工作表明,疫苗接种和入院之间没有联系.
科学领域:
- 神经学 神经学
- 疫苗学 疫苗学 疫苗学
- 流行病学 流行病学
背景情况:
- 2020年12月,BNT162b2 mRNA疫苗 (Pfizer-BioNTech) 在以色列推出,优先考虑60岁以上的人.
- 患者 (PWE) 对疫苗诱导的潜在发作恶化存在担忧.
- 缺乏将COVID-19疫苗与发作频率增加联系在一起的证据.
研究的目的:
- 评估BNT162b2 mRNA疫苗在患者新发作和复发性发作的影响.
- 评估疫苗接种运动之前和之后在急诊室的发病率.
主要方法:
- 从2017年1月到2021年5月,对被诊断患有发作的成年患者进行了回顾性分析,这些患者于2017年1月至2021年5月提交给特拉维夫苏拉斯基医疗中心的急诊室.
- 数据收集包括人口统计,临床信息和通过MDClone系统接种疫苗的状态.
- 将发病率和疫苗接种情况与国家疫苗接种数据进行比较,包括对60岁以上个体的次分析.
主要成果:
- 总共分析了1675个发作病例.
- 2021年紧急部门的访问和因而入院的病例与前几年相比,即使对整个ED访问量进行了调整.
- 由于而住院的患者的疫苗接种率反映了一般人口的疫苗接种率,疫苗接种和住院之间没有观察到时间关联.
结论:
- 以色列的高BNT162b2 mRNA疫苗接种率,特别是老年人中,与急诊室发作增加无关.
- 在COVID-19疫苗接种和发作相关住院治疗之间没有发现时间关系.
- 用Pfizer-BioNTech mRNA疫苗进行大规模疫苗接种与发作风险增加无关.
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