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Measurement of Fatty Acid β-Oxidation in a Suspension of Freshly Isolated Mouse Hepatocytes

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Published on: September 9, 2021

使用Lycium barbarum L.寡糖的微生物修饰可以减少小鼠肝纤维化和线粒体异常.

Zheng Zhang¹, Wenjia Lu¹, Pengfei Liu¹

¹State Key Laboratory of Biobased Material and Green Papermaking, School of Food Science and Engineering, Qilu University of Technology, Shandong Academy of Sciences, Jinan 250353, China.

Phytomedicine : international journal of phytotherapy and phytopharmacology

|September 10, 2023

概括

此摘要是机器生成的。

低分子量 Lycium barbarum L. 寡糖 (LBO) 作为益生菌,改善肠道微生物群,减少小鼠肝纤维化. 这些发现突显了LBO的价值.

关键词:

便代谢是便的代谢.便中的微生物组肝脏纤维化肝脏纤维化这种糖类是Lycium barbarum的寡糖.结构结构是一个结构.

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科学领域:

营养科学营养科学
微生物学微生物学
肝病学肝病学是一种肝病学.

背景情况:

草甘 (Lycium barbarum L.) (LBO) 是具有增强抗氧化和消化性质的低分子量寡糖.
虽然LBO在全球范围内被消费,但对肝病的治疗潜力仍然未被探索.
高分子量多糖与LBO相比,其疗效较低.

研究的目的:

为了研究LBO在治疗肝纤维化的疗效.
探索LBO在调节肠道微生物生态系统对肝脏健康的作用.

主要方法:

准备了LBO,并根据其化学结构进行了表征.
在小鼠中,碳四化物 (CCl4) 诱导的肝纤维化被用口服 LBO 治疗.
通过分析肠道微生物群,便代谢物和生理/生化标志物来评估影响.

主要成果:

一种pyranose循环寡糖类的LBO,作为一种益生菌,促进有益的肠道细菌 (例如,Bacillus,Tyzzerella).
补充LBO改善了微生物代谢,包括碳水化合物和维生素代谢,以及肠肝循环.
LBO降低了炎症性细胞因子和肝脏基,增强了线粒体功能,改善了肝纤维化.

结论:

作为一种前生物剂,LBO显示出显著的潜力.
通过调节肠道微生物群和改善宿主新陈代谢,LBO有效地减轻肝纤维化.
这些发现支持LBO作为肝纤维化的新疗法策略.