代谢在多个系统中配置免疫反应:从COVID-19中吸取教训
Tinku Gupta1, Najumuddin2, Dhanya Rajendran3
1Department of Pharmacognosy & Phytochemistry, School of Pharmaceutical Education and Research, Jamia Hamdard (Deemed University), M. B. Road, New Delhi 110062, India.
Advances in biological regulation
|September 10, 2023
概括
代谢功能障碍和免疫细胞变化与严重的COVID-19和长期的COVID (Cov-2的急性后续) 有关. 这项研究探讨了这些相互作用,用于针对慢性炎症和代谢变化的未来疗法.
科学领域:
- 免疫学 免疫学 免疫学
- 代谢性疾病研究研究.
- 传染病病理学 传染病病理学
背景情况:
- 糖尿病和肥胖等代谢性疾病与免疫细胞活性增加和炎症有关.
- 代谢功能障碍患者面临严重COVID-19和长期COVID (Cov-2的急性后续) 的更高风险.
研究的目的:
- 研究COVID-19中的代谢和免疫系统变化与COV-2的急性后续病变之间的联系.
- 通过了解潜在的致病机制,识别长期COVID的潜在治疗点.
主要方法:
- 审查有关代谢疾病,免疫反应和COVID-19的现有文献.
- 分析与COVID-19相关的器官系统的致病性代谢和免疫变化以及COV-2的急性后续.
主要成果:
- 免疫细胞的代谢重新连接与代谢疾病的严重程度有关.
- 慢性炎症和代谢功能障碍是长期COVID发展的关键因素.
结论:
- 致病性代谢和免疫相互作用可能是COVID-19和COV-2的急性后续病变的基础.
- 了解这些跨器官系统相互作用可以为长期COVID提供有针对性的治疗策略.
相关概念视频
01:29Immune Response Against Viral Pathogens
815
The immune system's response to viral infections is a complex and coordinated process involving natural killer (NK) cells, T cell-mediated responses, and antibody-mediated responses.
NK Cells
NK cells are a crucial part of our innate immune system, acting as the first line of defense against viral infections. These cells can recognize and kill infected cells without prior exposure to the virus, effectively slowing down the spread of infection. Additionally, NK cells produce proinflammatory...
NK Cells
NK cells are a crucial part of our innate immune system, acting as the first line of defense against viral infections. These cells can recognize and kill infected cells without prior exposure to the virus, effectively slowing down the spread of infection. Additionally, NK cells produce proinflammatory...
815
01:19Regulation of Metabolism
9.5K
Cellular needs and conditions vary from cell to cell and change within individual cells over time. For example, the required enzymes and energetic demands of stomach cells are different from those of fat storage cells, skin cells, blood cells, and nerve cells. Furthermore, a digestive cell works much harder to process and break down nutrients during the time that closely follows a meal compared with many hours after a meal. As these cellular demands and conditions vary, so do the amounts and...
9.5K
01:40Overview of Metabolism
30.8K
Living cells constantly carry out various chemical reactions which are necessary for their proper functioning. These reactions are interlinked to one another via multiple pathways. The collection of these chemical reactions is known as metabolism.
Plant Metabolism
Sunlight, the primary source of energy in plants, is first absorbed by the chlorophyll pigments present in their leaves. Plants then use this energy to carry out photosynthesis, where water is oxidized into oxygen and carbon dioxide...
Plant Metabolism
Sunlight, the primary source of energy in plants, is first absorbed by the chlorophyll pigments present in their leaves. Plants then use this energy to carry out photosynthesis, where water is oxidized into oxygen and carbon dioxide...
30.8K
00:52What is Metabolism?
114.6K
Overview
114.6K
01:38What is the Immune System?
111.6K
Overview
111.6K
01:30Introduction to Metabolism
71
Metabolism encompasses all biochemical reactions in a living organism, facilitating both the breakdown and synthesis of biomolecules. These metabolic processes are categorized into catabolic and anabolic pathways, which operate in a coordinated manner to ensure energy balance and cellular function.Catabolic Pathways and Energy ReleaseCatabolic pathways involve the breakdown of complex macromolecules such as carbohydrates, lipids, and proteins into smaller structures like monosaccharides, fatty...
71