世卫组织分类与消化道神经内分泌瘤的基于位置和功能的分类之间的关系
Noah C Helderman1, Manon Suerink1, Gül Kilinç2
1Department of Clinical Genetics, Leiden University Medical Centre, Leiden, The Netherlands.
Neuroendocrinology
|September 10, 2023
概括
对消化神经内分泌瘤 (NENs) 术语的误解阻碍了研究. 本综述澄清了NEN分类,旨在标准化术语,以改善未来的研究和对这些不同恶性瘤的临床理解.
科学领域:
- 胃肠道学和瘤学
- 瘤生物学和分类
背景情况:
- 消化神经内分泌瘤 (NENs) 是一个多样化且不断增长的瘤群.
- 目前在NEN中的挑战源于对分类和术语的误解和滥用.
- 神经内分泌瘤 (NETs) 和神经内分泌癌瘤 (NECs) 之间的区别,以及NETs的恶性性质,往往被混.
研究的目的:
- 审查和澄清用于分类消化道NENs的最新术语.
- 创建一个综述,将世卫组织分类与基于位置和功能的分类结合起来.
- 促进NEN的通用术语,以帮助研究和临床实践.
主要方法:
- 对消化系统NEN分类的最新术语的文献综述.
- 综合世界卫生组织 (WHO) 的分类与基于位置和功能的系统.
- 为NEN分类制定一个全面的概述.
主要成果:
- 发现了常见的误解,例如将3级NET与NEC混为一谈.
- 突出了NETs被错误地归类为良性,尽管它们具有转移潜力.
- 建立了消化系统NEN的综合分类框架.
结论:
- 标准化术语对于准确评估和比较NEN文献至关重要.
- 拟议的概述是临床医生和研究人员的指南.
- 全球采用清晰的NEN术语将为未来的研究提供基础.
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