相关实验视频
Updated: Jul 16, 2025

00:10
Precision Measurements and Parametric Models of Vertebral Endplates
Published on: September 17, 2019
6.5K
盘末板骨髓复杂分类:我们对莫迪脊椎末板变化及其临床相关性的理解取得了进展
Shanmuganathan Rajasekaran1, Pushpa Bt2, Chandhan Murugan1
1Department of Spine Surgery, Ganga Hospital, 313. Mettupalayam Rd, Coimbatore, Tamil Nadu, India.
The spine journal : official journal of the North American Spine Society
|September 10, 2023
概括
这项研究引入了脊柱退行症的新分类,即圆盘末板骨髓分类 (DEBC),与Modic变化 (MC) 相比,它可以更好地预测手术需要和感染风险. DEBC提供了更可靠的脊柱活动评估.
科学领域:
- 脊柱成像和退化研究.
- 先进的MRI技术用于脊柱评估.
背景情况:
- 脊柱退化涉及磁盘,端板和骨髓作为一个相互依赖的单元.
- 磁力共振成像 (MRI) 上的模态变化 (MC) 仅限于底骨,由于难以区分脂肪和,可能会误导疾病活动.
- 目前的MRI序列 (T1,T2) 在可靠评估脊髓退化活动方面存在局限性.
研究的目的:
- 评估脊柱退化整体,考虑盘,端板和骨髓复合体.
- 根据活动状态为脊柱退行症开发一个新的分类系统 (DEBC).
- 为了提高诊断准确性,将STIR MRI序列纳入.
主要方法:
- 一项观察性队列研究将腰部疼痛 (LBP) 患者与其他脊柱损伤的对照患者进行了比较.
- 使用T1,T2和STIRMRI序列开发了一种新的圆盘末板骨髓分类 (DEBC).
- DEBC将退化分为急性炎症 (A),慢性持续性 (B),潜伏性 (C) 和非活动性 (D) 状态,其中H+修饰器用于椎间盘.
主要成果:
- DEBC分类要求重新分类586个先前通过Modic变化 (MC) 评估的端板.
- B型DEBC (慢性持续活动) 是最常见的类型 (51.8%).
- 与对照组 (1,1%) 相比,使用H+修饰剂的DEBC在LBP患者 (23.3%) 的患病率显著更高,并且与需要手术的几率增加5.2倍有关.
- 与非DEBC (0.47%) 相比,DEBC分类显示术后感染的发病率较高 (2.4%).
结论:
- 与传统的Modic变化 (MC) 相比,开发的DEBC分类在评估脊柱退化方面提供了更高的准确性.
- DEBC为手术干预需求和手术后感染率提供了更好的可预测性.
- 该研究强调了MC的局限性以及全面的DEBC系统用于评估脊柱健康的优势.
相关概念视频
Bone Remodeling
38.4K
Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
38.4K
General Structure of a Vertebra
2.9K
A typical vertebra, with the exception of the sacrum and coccyx, consists of a body, a vertebral arch, and seven different projections termed processes. The anterior portion of the vertebrae, the body, supports about half the body’s weight. The vertebral bodies progressively increase in size and thickness from the cervical region to the lumbar region of the vertebral column. The intervertebral discs present between the bodies of adjacent vertebrae firmly unites them, forming a continuous...
2.9K
Classification of Bones
5.7K
The bones of the human skeletal system are of varied shapes, sizes, and functions. They can be classified based on their shape and function into four major classes: long bones, short bones, flat bones, and irregular bones. Some classifications include a fifth type, the sesamoid bones, as a separate class, whereas others categorize them under short bones.
Long and Short Bones
The appendicular skeleton, particularly the upper and lower limbs, is primarily made of long and short bones. The...
Long and Short Bones
The appendicular skeleton, particularly the upper and lower limbs, is primarily made of long and short bones. The...
5.7K
Bone Formation by Endochondral Ossification
4.6K
Bone formation, or ossification, begins around the sixth to seventh week of embryonic development. Most bones develop from a cartilaginous template through the process of endochondral ossification. Cartilage formation begins when clusters of mesenchymal cells differentiate into chondrocytes. These chondrocytes proliferate rapidly and secrete an extracellular matrix that becomes encased in a membrane called the perichondrium. The resulting cartilage model provides a template that resembles the...
4.6K
Bone Markings
5.4K
Bones have various surface features that help form joints and attach to other soft tissues. Depending on the function, bone markings are categorized into articulating projections, processes for attachment, depressions, and openings.
Articulating Projections
Articulating projections are found where two bones meet to form a joint. These structures are usually found at the ends of bones. The largest articulation is a rounded projection called the head, supported by a narrow neck at the ends of...
Articulating Projections
Articulating projections are found where two bones meet to form a joint. These structures are usually found at the ends of bones. The largest articulation is a rounded projection called the head, supported by a narrow neck at the ends of...
5.4K
Osteoclasts in Bone Remodeling
3.0K
Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during...
3.0K

